CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck
Abstract Background Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequa...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Cancer Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40644-021-00430-6 |
| _version_ | 1819036565151678464 |
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| author | Christiaan A. Rees Joshua H. Litchman Xiaotian Wu Mariah M. Servos Darcy A. Kerr Ryan J. Halter David A. Pastel Joseph A. Paydarfar |
| author_facet | Christiaan A. Rees Joshua H. Litchman Xiaotian Wu Mariah M. Servos Darcy A. Kerr Ryan J. Halter David A. Pastel Joseph A. Paydarfar |
| author_sort | Christiaan A. Rees |
| collection | DOAJ |
| description | Abstract Background Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequacy of planned lymph node dissection using preoperative data. The present study sought to evaluate CT-derived estimates of lymphatic tissue volumes as a preoperative tool to guide cervical node dissection. Methods Fifteen cervical lymph node dissections were performed in 14 subjects with HNSCCa. Preoperative CT-derived estimates of lymphatic tissue volumes were compared with gross pathology tissue volume estimates and pathologically-determined LNY. Results Resected tissue volume (calculated using the triaxial ellipsoid method) correlates with CT-derived preoperative lymphatic volume estimates (r = 0.74, p = 0.003) while LNY does not(r = − 0.12, p = 0.67). When excluding pathologically enlarged lymph nodes (“refined” data), a negative correlation was observed between refined CT-derived volume estimates and refined LNY (r = − 0.65, p = 0.009). Conclusion In the setting of cervical lymph node dissection, CT-derived lymphatic volume estimates correlate with resected tissue volume, but refined CT-derived volume estimates correlate negatively with refined LNY. Trial registration Retrospectively registered. Level of evidence 4 |
| first_indexed | 2024-12-21T08:07:32Z |
| format | Article |
| id | doaj.art-32aaf4994b864b8aa4d3dbff9244ca60 |
| institution | Directory Open Access Journal |
| issn | 1470-7330 |
| language | English |
| last_indexed | 2024-12-21T08:07:32Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj.art-32aaf4994b864b8aa4d3dbff9244ca602022-12-21T19:10:44ZengBMCCancer Imaging1470-73302021-11-012111710.1186/s40644-021-00430-6CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neckChristiaan A. Rees0Joshua H. Litchman1Xiaotian Wu2Mariah M. Servos3Darcy A. Kerr4Ryan J. Halter5David A. Pastel6Joseph A. Paydarfar7Geisel School of Medicine at DartmouthDepartment of Radiology, Dartmouth-Hitchcock Medical CenterThayer School of Engineering, Dartmouth CollegeGeisel School of Medicine at DartmouthGeisel School of Medicine at DartmouthGeisel School of Medicine at DartmouthGeisel School of Medicine at DartmouthGeisel School of Medicine at DartmouthAbstract Background Indices obtained from lymph node dissection specimens, specifically lymph node yield (LNY) and lymph node ratio (LNR), have prognostic significance in the setting of head and neck squamous cell carcinoma (HNSCCa). However, there are currently no validated tools to estimate adequacy of planned lymph node dissection using preoperative data. The present study sought to evaluate CT-derived estimates of lymphatic tissue volumes as a preoperative tool to guide cervical node dissection. Methods Fifteen cervical lymph node dissections were performed in 14 subjects with HNSCCa. Preoperative CT-derived estimates of lymphatic tissue volumes were compared with gross pathology tissue volume estimates and pathologically-determined LNY. Results Resected tissue volume (calculated using the triaxial ellipsoid method) correlates with CT-derived preoperative lymphatic volume estimates (r = 0.74, p = 0.003) while LNY does not(r = − 0.12, p = 0.67). When excluding pathologically enlarged lymph nodes (“refined” data), a negative correlation was observed between refined CT-derived volume estimates and refined LNY (r = − 0.65, p = 0.009). Conclusion In the setting of cervical lymph node dissection, CT-derived lymphatic volume estimates correlate with resected tissue volume, but refined CT-derived volume estimates correlate negatively with refined LNY. Trial registration Retrospectively registered. Level of evidence 4https://doi.org/10.1186/s40644-021-00430-63D reconstructionComputational modelingHead and neckLymph node ratioLymph node yieldNeck dissection |
| spellingShingle | Christiaan A. Rees Joshua H. Litchman Xiaotian Wu Mariah M. Servos Darcy A. Kerr Ryan J. Halter David A. Pastel Joseph A. Paydarfar CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck Cancer Imaging 3D reconstruction Computational modeling Head and neck Lymph node ratio Lymph node yield Neck dissection |
| title | CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck |
| title_full | CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck |
| title_fullStr | CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck |
| title_full_unstemmed | CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck |
| title_short | CT for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck |
| title_sort | ct for estimating adequacy of lymph node dissection in patients with squamous cell carcinoma of the head and neck |
| topic | 3D reconstruction Computational modeling Head and neck Lymph node ratio Lymph node yield Neck dissection |
| url | https://doi.org/10.1186/s40644-021-00430-6 |
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