Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters
In Bangladesh, the extensive use of fenitrothion on crops and in aquaculture ponds inevitably threatens a range of aquaculture species, including fish, owing to stress responses and physiological disturbances. The present study elucidated the potential toxic effects of fenitrothion on the blood biom...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750022000932 |
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| author | Rifat Farjana Ritu SM Majharul Islam Harunur Rashid Shahroz Mahean Haque Ilham Zulfahmi Kizar Ahmed Sumon |
| author_facet | Rifat Farjana Ritu SM Majharul Islam Harunur Rashid Shahroz Mahean Haque Ilham Zulfahmi Kizar Ahmed Sumon |
| author_sort | Rifat Farjana Ritu |
| collection | DOAJ |
| description | In Bangladesh, the extensive use of fenitrothion on crops and in aquaculture ponds inevitably threatens a range of aquaculture species, including fish, owing to stress responses and physiological disturbances. The present study elucidated the potential toxic effects of fenitrothion on the blood biomarkers (haemato-biochemistry and structure of erythrocytes) of stinging catfish (Heteropneustes fossilis), a commercially significant aquaculture species. Fish were exposed to four sub-lethal concentrations (0%, 10%, 20%, and 40% of the 96-h LC50 value) of fenitrothion in triplicate and observed on the 7th, 14th, 21st, and 28th day following exposure. With increasing fenitrothion concentration, blood glucose and white blood cell levels increased significantly; in contrast, hemoglobin, red blood cell, and packed cell volume substantially decreased. However, the mean corpuscular volume and mean corpuscular hemoglobin did not change significantly during the exordial period (0–7 d); although, at a later stage, changes were observed. Frequencies of observed erythrocytic nuclear abnormalities, such as degeneration, bi-nucleus, micronucleus, notch nucleus, and nuclear bridge and erythrocytic cellular abnormalities, such as echinocytes, fusion, elongation, and tear drop morphology increased significantly in a concentration-dependent manner. Differences between the control individuals and those individuals under treatment were considered insignificant for twin cells on the 14th day of exposure. The study showed the pernicious impact of the effects of fenitrothion on H. fossilis through physiological alteration, which is likely to pose challenges for aquaculture production. |
| first_indexed | 2024-04-12T02:31:54Z |
| format | Article |
| id | doaj.art-32abdc9e83384973a3994ce049b27b95 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-04-12T02:31:54Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-32abdc9e83384973a3994ce049b27b952022-12-22T03:51:45ZengElsevierToxicology Reports2214-75002022-01-019895904Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parametersRifat Farjana Ritu0SM Majharul Islam1Harunur Rashid2Shahroz Mahean Haque3Ilham Zulfahmi4Kizar Ahmed Sumon5Department of Fisheries Management, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh 2202, BangladeshDepartment of Fisheries Management, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh 2202, BangladeshDepartment of Fisheries Management, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh 2202, BangladeshDepartment of Fisheries Management, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh 2202, BangladeshDepartment of Fisheries Resources Utilization, Faculty of Marine and Fisheries, Syiah Kuala University, IndonesiaDepartment of Fisheries Management, Faculty of Fisheries, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh; Corresponding author.In Bangladesh, the extensive use of fenitrothion on crops and in aquaculture ponds inevitably threatens a range of aquaculture species, including fish, owing to stress responses and physiological disturbances. The present study elucidated the potential toxic effects of fenitrothion on the blood biomarkers (haemato-biochemistry and structure of erythrocytes) of stinging catfish (Heteropneustes fossilis), a commercially significant aquaculture species. Fish were exposed to four sub-lethal concentrations (0%, 10%, 20%, and 40% of the 96-h LC50 value) of fenitrothion in triplicate and observed on the 7th, 14th, 21st, and 28th day following exposure. With increasing fenitrothion concentration, blood glucose and white blood cell levels increased significantly; in contrast, hemoglobin, red blood cell, and packed cell volume substantially decreased. However, the mean corpuscular volume and mean corpuscular hemoglobin did not change significantly during the exordial period (0–7 d); although, at a later stage, changes were observed. Frequencies of observed erythrocytic nuclear abnormalities, such as degeneration, bi-nucleus, micronucleus, notch nucleus, and nuclear bridge and erythrocytic cellular abnormalities, such as echinocytes, fusion, elongation, and tear drop morphology increased significantly in a concentration-dependent manner. Differences between the control individuals and those individuals under treatment were considered insignificant for twin cells on the 14th day of exposure. The study showed the pernicious impact of the effects of fenitrothion on H. fossilis through physiological alteration, which is likely to pose challenges for aquaculture production.http://www.sciencedirect.com/science/article/pii/S2214750022000932Organophosphate insecticideLC50Blood biomarkersAquaculture speciesErythrocytic abnormalities |
| spellingShingle | Rifat Farjana Ritu SM Majharul Islam Harunur Rashid Shahroz Mahean Haque Ilham Zulfahmi Kizar Ahmed Sumon Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters Toxicology Reports Organophosphate insecticide LC50 Blood biomarkers Aquaculture species Erythrocytic abnormalities |
| title | Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters |
| title_full | Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters |
| title_fullStr | Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters |
| title_full_unstemmed | Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters |
| title_short | Application of fenitrothion on Heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters |
| title_sort | application of fenitrothion on heteropneustes fossilis causes alteration in morphology of erythrocytes via modifying hematological parameters |
| topic | Organophosphate insecticide LC50 Blood biomarkers Aquaculture species Erythrocytic abnormalities |
| url | http://www.sciencedirect.com/science/article/pii/S2214750022000932 |
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