Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy
In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of TCR signaling, T-cell development, and T-cell hom...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/20/14/3500 |
| _version_ | 1811198014013833216 |
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| author | Ursula Bommhardt Burkhart Schraven Luca Simeoni |
| author_facet | Ursula Bommhardt Burkhart Schraven Luca Simeoni |
| author_sort | Ursula Bommhardt |
| collection | DOAJ |
| description | In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of TCR signaling, T-cell development, and T-cell homeostasis. Because of the crucial role of Lck in T-cell responses, strategies have been employed to redirect Lck activity to improve the efficacy of chimeric antigen receptors (CARs) and to potentiate T-cell responses in cancer immunotherapy. In addition to the well-studied role of Lck in T cells, evidence has been accumulated suggesting that Lck is also expressed in the brain and in tumor cells, where it actively takes part in signaling processes regulating cellular functions like proliferation, survival and memory. Therefore, Lck has emerged as a novel druggable target molecule for the treatment of cancer and neuronal diseases. In this review, we will focus on these new functions of Lck. |
| first_indexed | 2024-04-12T01:25:09Z |
| format | Article |
| id | doaj.art-32abf667b01449be843106abf98fde11 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T01:25:09Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-32abf667b01449be843106abf98fde112022-12-22T03:53:41ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-07-012014350010.3390/ijms20143500ijms20143500Beyond TCR Signaling: Emerging Functions of Lck in Cancer and ImmunotherapyUrsula Bommhardt0Burkhart Schraven1Luca Simeoni2Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, GermanyInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, GermanyInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Strasse 44, 39120 Magdeburg, GermanyIn recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation of TCR signaling, T-cell development, and T-cell homeostasis. Because of the crucial role of Lck in T-cell responses, strategies have been employed to redirect Lck activity to improve the efficacy of chimeric antigen receptors (CARs) and to potentiate T-cell responses in cancer immunotherapy. In addition to the well-studied role of Lck in T cells, evidence has been accumulated suggesting that Lck is also expressed in the brain and in tumor cells, where it actively takes part in signaling processes regulating cellular functions like proliferation, survival and memory. Therefore, Lck has emerged as a novel druggable target molecule for the treatment of cancer and neuronal diseases. In this review, we will focus on these new functions of Lck.https://www.mdpi.com/1422-0067/20/14/3500LckT cellCARcancerleukemiabrain |
| spellingShingle | Ursula Bommhardt Burkhart Schraven Luca Simeoni Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy International Journal of Molecular Sciences Lck T cell CAR cancer leukemia brain |
| title | Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy |
| title_full | Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy |
| title_fullStr | Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy |
| title_full_unstemmed | Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy |
| title_short | Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy |
| title_sort | beyond tcr signaling emerging functions of lck in cancer and immunotherapy |
| topic | Lck T cell CAR cancer leukemia brain |
| url | https://www.mdpi.com/1422-0067/20/14/3500 |
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