Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature
Background: Adult-onset Still's disease (AOSD), which presents many non-specific symptoms, such as rash leukocytosis, spiking fever, and sore throat, is a rare auto inflammatory disease. Other clinical features that are frequently observed include lymphadenopathy, arthralgia, serositis, splenom...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-06-01
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| Series: | Iranian Journal of Immunology |
| Subjects: | |
| Online Access: | https://iji.sums.ac.ir/article_48524_9f43fc6fbd7ed1fa6dc484daedb59fe6.pdf |
| _version_ | 1798042708670939136 |
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| author | Yan Gao Weiguo Jin Fang Qian Qingsong Huang Ailing Ma |
| author_facet | Yan Gao Weiguo Jin Fang Qian Qingsong Huang Ailing Ma |
| author_sort | Yan Gao |
| collection | DOAJ |
| description | Background: Adult-onset Still's disease (AOSD), which presents many non-specific symptoms, such as rash leukocytosis, spiking fever, and sore throat, is a rare auto inflammatory disease. Other clinical features that are frequently observed include lymphadenopathy, arthralgia, serositis, splenomegaly, and hepatomegaly. Laboratory tests show high levels of C-reactive protein, ferritin, and erythrocyte sedimentation rate reflecting the systemic inflammatory process in AOSD patients. Case presentation: The patient was a middle-aged woman with a high fever (39.8 C), sore throat, rashes on limbs with pruritus, mainly at the joints (elbow, knee, and ankle), muscle aches, dizziness, infirmity, weakness, and poor appetite without arthralgia. The ferritin level was above 1500 (normal value: 14-233) ng/L. Antineutrophil, antinuclear antibodies, and rheumatoid factor were negative. Combining the symptoms such as fever, rash, stress-induced acute inflammation, arthritis, and ferritin levels, the patient was eventually diagnosed with adult Still's disease. She received methylprednisolone 40mg intravenously every 12 hours for one week. On the second week, the dose was reduced to 40mg in the morning and 20mg in the evening, and finally, the dose was reduced to 40mg oral intake in the morning and 8mg in the evening. After half a month of treatment, the patient's high fever and skin rashes subsided, and the other symptoms also gradually relieved. Conclusions: A case of a middle-aged woman diagnosed with adult Still's disease is reported, and the possible pathogenesis and treatment of the disease are discussed. This case highlights the importance of early diagnosis and timely treatment of adult Still's disease to prevent potentially fatal complications. |
| first_indexed | 2024-04-11T22:39:14Z |
| format | Article |
| id | doaj.art-32acc09d9a5e41cf8ccd05773fd7b64d |
| institution | Directory Open Access Journal |
| issn | 1735-1383 1735-367X |
| language | English |
| last_indexed | 2024-04-11T22:39:14Z |
| publishDate | 2022-06-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Immunology |
| spelling | doaj.art-32acc09d9a5e41cf8ccd05773fd7b64d2022-12-22T03:59:05ZengShiraz University of Medical SciencesIranian Journal of Immunology1735-13831735-367X2022-06-0119220721210.22034/iji.2022.92228.213748524Case Report of a Female Patient with Adult-onset Still's Disease and Review of the LiteratureYan Gao0Weiguo Jin1Fang Qian2Qingsong Huang3Ailing Ma4Department of Pharmacy, Jiading District Hospital of Traditional Chinese Medicine, Shanghai 201800, ChinaDepartment of Administration Office, Jiading District Hospital of Traditional Chinese Medicine, Shanghai 201800, ChinaDepartment of Pharmacy, Jiading District Hospital of Traditional Chinese Medicine, Shanghai 201800, ChinaDepartment of Internal Medicine, Jiading District Hospital of Traditional Chinese Medicine, Shanghai 201800, ChinaDepartment of Internal Medicine, Jiading District Hospital of Traditional Chinese Medicine, Shanghai 201800, ChinaBackground: Adult-onset Still's disease (AOSD), which presents many non-specific symptoms, such as rash leukocytosis, spiking fever, and sore throat, is a rare auto inflammatory disease. Other clinical features that are frequently observed include lymphadenopathy, arthralgia, serositis, splenomegaly, and hepatomegaly. Laboratory tests show high levels of C-reactive protein, ferritin, and erythrocyte sedimentation rate reflecting the systemic inflammatory process in AOSD patients. Case presentation: The patient was a middle-aged woman with a high fever (39.8 C), sore throat, rashes on limbs with pruritus, mainly at the joints (elbow, knee, and ankle), muscle aches, dizziness, infirmity, weakness, and poor appetite without arthralgia. The ferritin level was above 1500 (normal value: 14-233) ng/L. Antineutrophil, antinuclear antibodies, and rheumatoid factor were negative. Combining the symptoms such as fever, rash, stress-induced acute inflammation, arthritis, and ferritin levels, the patient was eventually diagnosed with adult Still's disease. She received methylprednisolone 40mg intravenously every 12 hours for one week. On the second week, the dose was reduced to 40mg in the morning and 20mg in the evening, and finally, the dose was reduced to 40mg oral intake in the morning and 8mg in the evening. After half a month of treatment, the patient's high fever and skin rashes subsided, and the other symptoms also gradually relieved. Conclusions: A case of a middle-aged woman diagnosed with adult Still's disease is reported, and the possible pathogenesis and treatment of the disease are discussed. This case highlights the importance of early diagnosis and timely treatment of adult Still's disease to prevent potentially fatal complications.https://iji.sums.ac.ir/article_48524_9f43fc6fbd7ed1fa6dc484daedb59fe6.pdfadult-onset still’s diseasecase reportinflammatory disorder |
| spellingShingle | Yan Gao Weiguo Jin Fang Qian Qingsong Huang Ailing Ma Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature Iranian Journal of Immunology adult-onset still’s disease case report inflammatory disorder |
| title | Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature |
| title_full | Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature |
| title_fullStr | Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature |
| title_full_unstemmed | Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature |
| title_short | Case Report of a Female Patient with Adult-onset Still's Disease and Review of the Literature |
| title_sort | case report of a female patient with adult onset still s disease and review of the literature |
| topic | adult-onset still’s disease case report inflammatory disorder |
| url | https://iji.sums.ac.ir/article_48524_9f43fc6fbd7ed1fa6dc484daedb59fe6.pdf |
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