Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area
Liver steatosis is a chronic liver disease that is becoming one of the most important global health problems, due to its direct connection with metabolic syndrome, its significant impact on patients’ socioeconomic status and frailty, and the occurrence of advanced chronic liver disease. In recent ye...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2822 |
| _version_ | 1797465563884158976 |
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| author | Andrej Hari |
| author_facet | Andrej Hari |
| author_sort | Andrej Hari |
| collection | DOAJ |
| description | Liver steatosis is a chronic liver disease that is becoming one of the most important global health problems, due to its direct connection with metabolic syndrome, its significant impact on patients’ socioeconomic status and frailty, and the occurrence of advanced chronic liver disease. In recent years, there has been rapid technological progress in the ultrasound-based diagnostics field that can help us to quantitatively assess liver steatosis, including continuous attenuation parameters in A and B ultrasound modes, backscatter coefficients (e.g., speed of sound) and ultrasound envelope statistic parametric imaging. The methods used in this field are widely available, have favorable time and financial profiles, and are well accepted by patients. Less is known about their reliability in defining the presence and degree of liver steatosis. Numerous study reports have shown the methods’ favorable negative and positive predictive values in comparison with reference investigations (liver biopsy and MRI). Important research has also evaluated the role of these methods in diagnosing and monitoring non-alcoholic fatty liver disease (NAFLD). Since NAFLD is becoming the dominant global cause of liver cirrhosis, and due to the close but complex interplay of liver steatosis with the coexistence of liver fibrosis, knowledge regarding NAFLD’s influence on the progression of liver fibrosis is of crucial importance. Study findings, therefore, indicate the possibility of using these same diagnostic methods to evaluate the impact of NAFLD on the patient’s liver fibrosis progression risk, metabolic risk factors, cardiovascular complications, and the occurrence of hepatocellular carcinoma. The mentioned areas are particularly important in light of the fact that most of the known chronic liver disease etiologies are increasingly intertwined with the simultaneous presence of NAFLD. |
| first_indexed | 2024-03-09T18:23:14Z |
| format | Article |
| id | doaj.art-32adebe241ed4663b0bea02178e14a1f |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T18:23:14Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-32adebe241ed4663b0bea02178e14a1f2023-11-24T08:04:50ZengMDPI AGDiagnostics2075-44182022-11-011211282210.3390/diagnostics12112822Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease AreaAndrej Hari0Oddelek za Bolezni Prebavil, Splošna Bolnišnica Celje, Oblakova Cesta 3, 3000 Celje, SloveniaLiver steatosis is a chronic liver disease that is becoming one of the most important global health problems, due to its direct connection with metabolic syndrome, its significant impact on patients’ socioeconomic status and frailty, and the occurrence of advanced chronic liver disease. In recent years, there has been rapid technological progress in the ultrasound-based diagnostics field that can help us to quantitatively assess liver steatosis, including continuous attenuation parameters in A and B ultrasound modes, backscatter coefficients (e.g., speed of sound) and ultrasound envelope statistic parametric imaging. The methods used in this field are widely available, have favorable time and financial profiles, and are well accepted by patients. Less is known about their reliability in defining the presence and degree of liver steatosis. Numerous study reports have shown the methods’ favorable negative and positive predictive values in comparison with reference investigations (liver biopsy and MRI). Important research has also evaluated the role of these methods in diagnosing and monitoring non-alcoholic fatty liver disease (NAFLD). Since NAFLD is becoming the dominant global cause of liver cirrhosis, and due to the close but complex interplay of liver steatosis with the coexistence of liver fibrosis, knowledge regarding NAFLD’s influence on the progression of liver fibrosis is of crucial importance. Study findings, therefore, indicate the possibility of using these same diagnostic methods to evaluate the impact of NAFLD on the patient’s liver fibrosis progression risk, metabolic risk factors, cardiovascular complications, and the occurrence of hepatocellular carcinoma. The mentioned areas are particularly important in light of the fact that most of the known chronic liver disease etiologies are increasingly intertwined with the simultaneous presence of NAFLD.https://www.mdpi.com/2075-4418/12/11/2822ultrasoundattenuationpredictive valueliver steatosisnon-alcoholic fatty liver diseasemetabolic syndrome |
| spellingShingle | Andrej Hari Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area Diagnostics ultrasound attenuation predictive value liver steatosis non-alcoholic fatty liver disease metabolic syndrome |
| title | Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area |
| title_full | Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area |
| title_fullStr | Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area |
| title_full_unstemmed | Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area |
| title_short | Ultrasound-Based Diagnostic Methods: Possible Use in Fatty Liver Disease Area |
| title_sort | ultrasound based diagnostic methods possible use in fatty liver disease area |
| topic | ultrasound attenuation predictive value liver steatosis non-alcoholic fatty liver disease metabolic syndrome |
| url | https://www.mdpi.com/2075-4418/12/11/2822 |
| work_keys_str_mv | AT andrejhari ultrasoundbaseddiagnosticmethodspossibleuseinfattyliverdiseasearea |