A Randomized, Double-Blind, Single-Dose Study Comparing the Biosimilarity of HOT-1010 With Bevacizumab (Avastin®) in Chinese Healthy Male Subjects

A Randomized, Double-Blind, Single-Dose Study Comparing the Biosimilarity of HOT-1010 With Bevacizumab (Avastin®) in Chinese Healthy Male Subjects

Objective: This study was conducted to compare the pharmacokinetics, safety and immunogenicity of HOT-1010 with bevacizumab (Avastin®) in Chinese healthy male subjects.Methods: A single-center, randomized, double-blind, single-dose, parallel trial was performed in 84 Chinese healthy male subjects wh...

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Bibliographic Details
Main Authors: Kai Huang, Linling Que, Ying Ding, Nannan Chu, Zhenzhong Qian, Yunfei Shi, Wei Qin, Zhenni Li, Yuanxin Chen, Xianghong Gu, Jiakun Wang, Lin Zhang, Jisheng Zhang, Xiangyang Zhu, Yongmin Yang, Yuan Tang, Qing He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Pharmacology
Subjects:
biosimilarity
pharmacokinetics
bevacizumab
Immunogenicity
Avastin®
HOT-1010
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.694375/full

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