Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer

Integrated analyses of multi-omics reveal global patterns of methylation and hydroxymethylation and screen the tumor suppressive roles of HADHB in colorectal cancer

Abstract Background DNA methylation is an important epigenetic modification, associated with gene expression. 5-Methylcytosine and 5-hydroxymethylcytosine are two epigenetic hallmarks that maintain the equilibrium of epigenetic reprogramming. Disequilibrium in genomic methylation leads to carcinogen...

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Bibliographic Details
Main Authors: Yimin Zhu, Hanlin Lu, Dandan Zhang, Meiyan Li, Xiaohui Sun, Ledong Wan, Dan Yu, Yiping Tian, Hongchuan Jin, Aifen Lin, Fei Gao, Maode Lai
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
DNA hydroxymethylation
Sequencing
Colorectal cancer
Epigenetic
Online Access:http://link.springer.com/article/10.1186/s13148-018-0458-3

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