Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol
In pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current res...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/2409-9279/6/5/88 |
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| author | Lauren J. Klein John Benaiah Ayete-Nyampong Annette M. Williams Lori A. Harding Samuel A. Oppong Sari Acra Michael R. DeBaun Aamer Imdad |
| author_facet | Lauren J. Klein John Benaiah Ayete-Nyampong Annette M. Williams Lori A. Harding Samuel A. Oppong Sari Acra Michael R. DeBaun Aamer Imdad |
| author_sort | Lauren J. Klein |
| collection | DOAJ |
| description | In pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current research on the nutritional status of pregnant women with SCD and pregnancy outcomes. First, we aim to assess the burden of malnutrition in pregnant women with SCD. Next, we aim to systematically evaluate if pregnant women with SCD who have poor nutritional status are at increased risk for adverse birth outcomes compared to pregnant women with sickle cell disease and normal nutritional status. We will systematically search multiple electronic databases. Our exposure is pregnant women with SCD and poor nutritional status. The primary outcomes of interest include low birth weight (categorical) and birth weight z-scores (continuous). We will also evaluate maternal and perinatal outcomes as secondary outcomes. We will evaluate the risk of bias and overall certainty of evidence with Risk of Bias in Non-randomized Studies—of Interventions (ROBINS-I), and the overall evidence will be assessed using Grading of Recommendation Assessment, Development, and Evaluation (GRADE) criteria. We will pool findings with a meta-analysis if sufficient homogeneity exists among studies. Findings will be published in a peer-reviewed journal and disseminated to SCD advocacy groups. PROSPERO registration number: CRD42023429412. |
| first_indexed | 2024-03-10T21:00:26Z |
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| institution | Directory Open Access Journal |
| issn | 2409-9279 |
| language | English |
| last_indexed | 2024-03-10T21:00:26Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Methods and Protocols |
| spelling | doaj.art-32b1f6377eae4e9c8173d994881162c42023-11-19T17:35:00ZengMDPI AGMethods and Protocols2409-92792023-09-01658810.3390/mps6050088Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis ProtocolLauren J. Klein0John Benaiah Ayete-Nyampong1Annette M. Williams2Lori A. Harding3Samuel A. Oppong4Sari Acra5Michael R. DeBaun6Aamer Imdad7Department of Pediatrics, D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition at Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN 37232, USADepartment of Haematology, University of Ghana Medical School, Accra P.O. Box 77, GhanaCenter for Knowledge Management, Vanderbilt University Medical Center, Nashville, TN 37232, USACenter for Knowledge Management, Vanderbilt University Medical Center, Nashville, TN 37232, USADepartment of Obstetrics and Gynaecology, University of Ghana Medical School, Accra P.O. Box 77, GhanaDepartment of Pediatrics, D. Brent Polk Division of Pediatric Gastroenterology, Hepatology, and Nutrition at Monroe Carell Jr. Children’s Hospital at Vanderbilt, Nashville, TN 37232, USAVanderbilt Institute for Global Health, Vanderbilt University Medical Center, Nashville, TN 37232, USADepartment of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USAIn pregnancies complicated by sickle cell disease (SCD), the maternal-fetal dyad is at high risk for mortality and morbidity. In healthy pregnancies, maternal nutritional status is a critical factor for the healthy growth and development of the fetus. However, there are no reviews of the current research on the nutritional status of pregnant women with SCD and pregnancy outcomes. First, we aim to assess the burden of malnutrition in pregnant women with SCD. Next, we aim to systematically evaluate if pregnant women with SCD who have poor nutritional status are at increased risk for adverse birth outcomes compared to pregnant women with sickle cell disease and normal nutritional status. We will systematically search multiple electronic databases. Our exposure is pregnant women with SCD and poor nutritional status. The primary outcomes of interest include low birth weight (categorical) and birth weight z-scores (continuous). We will also evaluate maternal and perinatal outcomes as secondary outcomes. We will evaluate the risk of bias and overall certainty of evidence with Risk of Bias in Non-randomized Studies—of Interventions (ROBINS-I), and the overall evidence will be assessed using Grading of Recommendation Assessment, Development, and Evaluation (GRADE) criteria. We will pool findings with a meta-analysis if sufficient homogeneity exists among studies. Findings will be published in a peer-reviewed journal and disseminated to SCD advocacy groups. PROSPERO registration number: CRD42023429412.https://www.mdpi.com/2409-9279/6/5/88sickle cell anemiapregnancynutritional statussystematic review |
| spellingShingle | Lauren J. Klein John Benaiah Ayete-Nyampong Annette M. Williams Lori A. Harding Samuel A. Oppong Sari Acra Michael R. DeBaun Aamer Imdad Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol Methods and Protocols sickle cell anemia pregnancy nutritional status systematic review |
| title | Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol |
| title_full | Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol |
| title_fullStr | Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol |
| title_full_unstemmed | Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol |
| title_short | Epidemiology of Maternal Nutritional Status and Risk of Adverse Birth Outcomes in Undernourished Mothers with Sickle Cell Disease: A Systematic Review and Meta-Analysis Protocol |
| title_sort | epidemiology of maternal nutritional status and risk of adverse birth outcomes in undernourished mothers with sickle cell disease a systematic review and meta analysis protocol |
| topic | sickle cell anemia pregnancy nutritional status systematic review |
| url | https://www.mdpi.com/2409-9279/6/5/88 |
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