Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort study
Abstract Background Nonpersistence in anticoagulation therapy is common and associated with undesirable clinical outcomes in patients with venous thromboembolism (VTE). Methods We investigated preceding clinical events of treatment nonpersistence (e.g., switching, discontinuing, or restarting) in VT...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.6626 |
| _version_ | 1797542453767569408 |
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| author | Dongwon Yoon Han Eol Jeong Songhwa Choi Daye Lee Ju‐Young Shin Soo‐Mee Bang |
| author_facet | Dongwon Yoon Han Eol Jeong Songhwa Choi Daye Lee Ju‐Young Shin Soo‐Mee Bang |
| author_sort | Dongwon Yoon |
| collection | DOAJ |
| description | Abstract Background Nonpersistence in anticoagulation therapy is common and associated with undesirable clinical outcomes in patients with venous thromboembolism (VTE). Methods We investigated preceding clinical events of treatment nonpersistence (e.g., switching, discontinuing, or restarting) in VTE patients with and without active cancer using Korean claims database. Results Clinically significant events including thromboembolic events, hepatic function change and surgery preceded treatment nonpersistence, but heterogeneous distributions of clinical events were observed in the presence of active cancer. Patients with active cancer had a low rate of clinical events preceding treatment nonpersistence, and new active cancer diagnosis in the nonactive cancer group was most common before the switch to parenteral anticoagulants from warfarin or non‐vitamin K antagonist oral anticoagulants (NOACs). Conclusion These findings suggest that clinically significant events can precede treatment nonpersistence and largely paralleled current guidelines for patients with VTE, whereas heterogeneous distributions of clinical events were observed in the presence of active cancer. |
| first_indexed | 2024-03-10T13:30:45Z |
| format | Article |
| id | doaj.art-32b40fe1e0404f9abf35e63ad38ecc3e |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-10T13:30:45Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-32b40fe1e0404f9abf35e63ad38ecc3e2023-11-21T07:57:35ZengWileyCancer Medicine2045-76342023-11-011221205382054310.1002/cam4.6626Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort studyDongwon Yoon0Han Eol Jeong1Songhwa Choi2Daye Lee3Ju‐Young Shin4Soo‐Mee Bang5School of Pharmacy Sungkyunkwan University Suwon South KoreaSchool of Pharmacy Sungkyunkwan University Suwon South KoreaMedical Affairs Pfizer Korea Ltd. Seoul South KoreaMedical Affairs Pfizer Korea Ltd. Seoul South KoreaSchool of Pharmacy Sungkyunkwan University Suwon South KoreaDivision of Hemato‐Oncology, Department of Internal Medicine, Seoul National University College of Medicine Seoul National University Bundang Hospital Seongnam South KoreaAbstract Background Nonpersistence in anticoagulation therapy is common and associated with undesirable clinical outcomes in patients with venous thromboembolism (VTE). Methods We investigated preceding clinical events of treatment nonpersistence (e.g., switching, discontinuing, or restarting) in VTE patients with and without active cancer using Korean claims database. Results Clinically significant events including thromboembolic events, hepatic function change and surgery preceded treatment nonpersistence, but heterogeneous distributions of clinical events were observed in the presence of active cancer. Patients with active cancer had a low rate of clinical events preceding treatment nonpersistence, and new active cancer diagnosis in the nonactive cancer group was most common before the switch to parenteral anticoagulants from warfarin or non‐vitamin K antagonist oral anticoagulants (NOACs). Conclusion These findings suggest that clinically significant events can precede treatment nonpersistence and largely paralleled current guidelines for patients with VTE, whereas heterogeneous distributions of clinical events were observed in the presence of active cancer.https://doi.org/10.1002/cam4.6626active canceranticoagulant treatmentclinical eventsnonpersistencevenous thromboembolism |
| spellingShingle | Dongwon Yoon Han Eol Jeong Songhwa Choi Daye Lee Ju‐Young Shin Soo‐Mee Bang Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort study Cancer Medicine active cancer anticoagulant treatment clinical events nonpersistence venous thromboembolism |
| title | Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort study |
| title_full | Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort study |
| title_fullStr | Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort study |
| title_full_unstemmed | Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort study |
| title_short | Heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer: A nationwide cohort study |
| title_sort | heterogeneous distributions in clinical events preceding anticoagulant treatment nonpersistence in patients with venous thromboembolism stratified by active cancer a nationwide cohort study |
| topic | active cancer anticoagulant treatment clinical events nonpersistence venous thromboembolism |
| url | https://doi.org/10.1002/cam4.6626 |
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