Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread
A 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2016-05-01
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| Series: | Journal of Pathology and Translational Medicine |
| Subjects: | |
| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2015-08-08.pdf |
| _version_ | 1818997158489096192 |
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| author | Na Rae Kim Hyun Yee Cho Jeong-Heum Baek Juhyeon Jeong Seung Yeon Ha Jae Yeon Seok Sung Won Park Sun Jin Sym Kyu Chan Lee Dong Hae Chung |
| author_facet | Na Rae Kim Hyun Yee Cho Jeong-Heum Baek Juhyeon Jeong Seung Yeon Ha Jae Yeon Seok Sung Won Park Sun Jin Sym Kyu Chan Lee Dong Hae Chung |
| author_sort | Na Rae Kim |
| collection | DOAJ |
| description | A 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft tissue lesion in the right perianal area. Inguinal lymph node dissection and Mils’ operation extended to perianal and perivulvar skin was performed. Histologically, the anal canal lesion was composed of mucin-containing signet ring cells, which were similar to those found in Pagetoid skin lesions. It was diagnosed as an anal canal signet ring cell carcinoma (SRCC) with perianal and vulvar Pagetoid spread and bilateral inguinal lymph node metastasis. Anal canal SRCC is rare, and the current case is the third reported case in the English literature. Seven additional cases were retrieved from the world literature. Here, we describe this rare case of anal canal SRCC with perianal Pagetoid spread and provide a literature review. |
| first_indexed | 2024-12-20T21:41:11Z |
| format | Article |
| id | doaj.art-32b7f962db6c4b578a1d273e6a8d4386 |
| institution | Directory Open Access Journal |
| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-20T21:41:11Z |
| publishDate | 2016-05-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-32b7f962db6c4b578a1d273e6a8d43862022-12-21T19:25:47ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452016-05-0150323123710.4132/jptm.2015.08.0816555Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid SpreadNa Rae KimHyun Yee ChoJeong-Heum Baek0Juhyeon JeongSeung Yeon HaJae Yeon SeokSung Won Park1Sun Jin Sym2Kyu Chan Lee3Dong Hae Chung Department of General Surgery, Gachon University Gil Medical Center, Incheon, Korea Department of General Surgery, Gachon University Gil Medical Center, Incheon, Korea Division of Hematology and Oncology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea Department of Radiation Oncology, Gachon University Gil Medical Center, Incheon, KoreaA 61-year-old woman was referred to surgery for incidentally found colonic polyps during a health examination. Physical examination revealed widespread eczematous skin lesion without pruritus in the perianal and vulvar area. Abdominopelvic computed tomography showed an approximately 4-cm-sized, soft tissue lesion in the right perianal area. Inguinal lymph node dissection and Mils’ operation extended to perianal and perivulvar skin was performed. Histologically, the anal canal lesion was composed of mucin-containing signet ring cells, which were similar to those found in Pagetoid skin lesions. It was diagnosed as an anal canal signet ring cell carcinoma (SRCC) with perianal and vulvar Pagetoid spread and bilateral inguinal lymph node metastasis. Anal canal SRCC is rare, and the current case is the third reported case in the English literature. Seven additional cases were retrieved from the world literature. Here, we describe this rare case of anal canal SRCC with perianal Pagetoid spread and provide a literature review.http://www.jpatholtm.org/upload/pdf/jptm-2015-08-08.pdfCarcinoma, signet ring cellAnal canalPaget disease, extramammary |
| spellingShingle | Na Rae Kim Hyun Yee Cho Jeong-Heum Baek Juhyeon Jeong Seung Yeon Ha Jae Yeon Seok Sung Won Park Sun Jin Sym Kyu Chan Lee Dong Hae Chung Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread Journal of Pathology and Translational Medicine Carcinoma, signet ring cell Anal canal Paget disease, extramammary |
| title | Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread |
| title_full | Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread |
| title_fullStr | Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread |
| title_full_unstemmed | Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread |
| title_short | Rare Case of Anal Canal Signet Ring Cell Carcinoma Associated with Perianal and Vulvar Pagetoid Spread |
| title_sort | rare case of anal canal signet ring cell carcinoma associated with perianal and vulvar pagetoid spread |
| topic | Carcinoma, signet ring cell Anal canal Paget disease, extramammary |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2015-08-08.pdf |
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