INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS
Abstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/659 |
| _version_ | 1797198004948566016 |
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| author | M. A. Apresova I. E. Efremova A. A. Babayants S. B. Cheknev |
| author_facet | M. A. Apresova I. E. Efremova A. A. Babayants S. B. Cheknev |
| author_sort | M. A. Apresova |
| collection | DOAJ |
| description | Abstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355.0±480.98 pg/ ml. The complexes of γ-globulin with zinc (48 h of culture) caused increase of IL-8 production that was 1.8-fold higher than with control γ-globulin and 1.4-fold higher than with of zinc ions alone (p < 0.02). Dynamic tracking of the cytokine levels has shown that PBCs induced with γ-globulin/metal complexes produced IL8 as a factor of prolonged or late-type response. |
| first_indexed | 2024-03-08T05:49:29Z |
| format | Article |
| id | doaj.art-32b8305179e04f3fa24ee3d3d8f07523 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:52:58Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-32b8305179e04f3fa24ee3d3d8f075232024-04-22T13:07:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0115543143810.15789/1563-0625-2013-5-431-438656INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONSM. A. Apresova0I. E. Efremova1A. A. Babayants2S. B. Cheknev3Federal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, MoscowFederal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, MoscowFederal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, MoscowFederal State Gamaleya Research Institute for Epidemiology and Microbiology, Russian Ministry of Health Care, MoscowAbstract. This study has shown detectable production of IL-8, as a fraction of cytokine pool induced in culture of human peripheral blood cells (PBCs). Mean amounts of IL8 produced in presence of γ-globulin fraction proteins and/or their metal complexes with zinc ions varied from 575.0±27.77 to 6355.0±480.98 pg/ ml. The complexes of γ-globulin with zinc (48 h of culture) caused increase of IL-8 production that was 1.8-fold higher than with control γ-globulin and 1.4-fold higher than with of zinc ions alone (p < 0.02). Dynamic tracking of the cytokine levels has shown that PBCs induced with γ-globulin/metal complexes produced IL8 as a factor of prolonged or late-type response.https://www.mimmun.ru/mimmun/article/view/659γ-globulinmetal complexesinductionil-8 |
| spellingShingle | M. A. Apresova I. E. Efremova A. A. Babayants S. B. Cheknev INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS Медицинская иммунология γ-globulin metal complexes induction il-8 |
| title | INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS |
| title_full | INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS |
| title_fullStr | INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS |
| title_full_unstemmed | INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS |
| title_short | INDUCTION OF IL-8 PRODUCTION BY THE METAL COMPLEXES OF γ-GLOBULIN FORMED WITH ZINC IONS |
| title_sort | induction of il 8 production by the metal complexes of γ globulin formed with zinc ions |
| topic | γ-globulin metal complexes induction il-8 |
| url | https://www.mimmun.ru/mimmun/article/view/659 |
| work_keys_str_mv | AT maapresova inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions AT ieefremova inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions AT aababayants inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions AT sbcheknev inductionofil8productionbythemetalcomplexesofgglobulinformedwithzincions |