Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy
Radiotherapy represents a highly targeted and efficient treatment choice in many cancer types, both with curative and palliative intents. Nevertheless, radioresistance, consisting in the adaptive response of the tumor to radiation-induced damage, represents a major clinical problem. A growing body o...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11343 |
| _version_ | 1797479100543139840 |
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| author | Mattia Zaffaroni Maria Giulia Vincini Giulia Corrao Giulia Marvaso Matteo Pepa Giuseppe Viglietto Nicola Amodio Barbara Alicja Jereczek-Fossa |
| author_facet | Mattia Zaffaroni Maria Giulia Vincini Giulia Corrao Giulia Marvaso Matteo Pepa Giuseppe Viglietto Nicola Amodio Barbara Alicja Jereczek-Fossa |
| author_sort | Mattia Zaffaroni |
| collection | DOAJ |
| description | Radiotherapy represents a highly targeted and efficient treatment choice in many cancer types, both with curative and palliative intents. Nevertheless, radioresistance, consisting in the adaptive response of the tumor to radiation-induced damage, represents a major clinical problem. A growing body of the literature suggests that mechanisms related to mitochondrial changes and metabolic remodeling might play a major role in radioresistance development. In this work, the main contributors to the acquired cellular radioresistance and their relation with mitochondrial changes in terms of reactive oxygen species, hypoxia, and epigenetic alterations have been discussed. We focused on recent findings pointing to a major role of mitochondria in response to radiotherapy, along with their implication in the mechanisms underlying radioresistance and radiosensitivity, and briefly summarized some of the recently proposed mitochondria-targeting strategies to overcome the radioresistant phenotype in cancer. |
| first_indexed | 2024-03-09T21:40:54Z |
| format | Article |
| id | doaj.art-32b8c40b6e144c90be5664a97a5355e7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:40:54Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-32b8c40b6e144c90be5664a97a5355e72023-11-23T20:31:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123191134310.3390/ijms231911343Unraveling Mitochondrial Determinants of Tumor Response to Radiation TherapyMattia Zaffaroni0Maria Giulia Vincini1Giulia Corrao2Giulia Marvaso3Matteo Pepa4Giuseppe Viglietto5Nicola Amodio6Barbara Alicja Jereczek-Fossa7Division of Radiation Oncology, IEO—European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO—European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO—European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO—European Institute of Oncology, IRCCS, 20141 Milan, ItalyDivision of Radiation Oncology, IEO—European Institute of Oncology, IRCCS, 20141 Milan, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, ItalyDivision of Radiation Oncology, IEO—European Institute of Oncology, IRCCS, 20141 Milan, ItalyRadiotherapy represents a highly targeted and efficient treatment choice in many cancer types, both with curative and palliative intents. Nevertheless, radioresistance, consisting in the adaptive response of the tumor to radiation-induced damage, represents a major clinical problem. A growing body of the literature suggests that mechanisms related to mitochondrial changes and metabolic remodeling might play a major role in radioresistance development. In this work, the main contributors to the acquired cellular radioresistance and their relation with mitochondrial changes in terms of reactive oxygen species, hypoxia, and epigenetic alterations have been discussed. We focused on recent findings pointing to a major role of mitochondria in response to radiotherapy, along with their implication in the mechanisms underlying radioresistance and radiosensitivity, and briefly summarized some of the recently proposed mitochondria-targeting strategies to overcome the radioresistant phenotype in cancer.https://www.mdpi.com/1422-0067/23/19/11343mitochondriaradiotherapyradioresistanceROStumor hypoxiamitochondria-targeting compounds |
| spellingShingle | Mattia Zaffaroni Maria Giulia Vincini Giulia Corrao Giulia Marvaso Matteo Pepa Giuseppe Viglietto Nicola Amodio Barbara Alicja Jereczek-Fossa Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy International Journal of Molecular Sciences mitochondria radiotherapy radioresistance ROS tumor hypoxia mitochondria-targeting compounds |
| title | Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy |
| title_full | Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy |
| title_fullStr | Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy |
| title_full_unstemmed | Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy |
| title_short | Unraveling Mitochondrial Determinants of Tumor Response to Radiation Therapy |
| title_sort | unraveling mitochondrial determinants of tumor response to radiation therapy |
| topic | mitochondria radiotherapy radioresistance ROS tumor hypoxia mitochondria-targeting compounds |
| url | https://www.mdpi.com/1422-0067/23/19/11343 |
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