Scn1a gene reactivation after symptom onset rescues pathological phenotypes in a mouse model of Dravet syndrome
Dravet syndrome is a devastating epileptic encephalopathy caused by Scn1a gene haploinsufficiency. Exploiting a novel knock-in mouse model, here the authors show that restoring Scn1a expression after symptom onset is sufficient to rescue main phenotypic manifestations of the syndrome.
Bibliographic Details
| Main Authors: |
Nicholas Valassina,
Simone Brusco,
Alessia Salamone,
Linda Serra,
Mirko Luoni,
Serena Giannelli,
Simone Bido,
Luca Massimino,
Federica Ungaro,
Pietro Giuseppe Mazzara,
Patrizia D’Adamo,
Gabriele Lignani,
Vania Broccoli,
Gaia Colasante |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-27837-w
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