The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index
The aim of this research was to assess lipid peroxidation (LPO) and antioxidative defense (AOD) changes in adolescent boys with obesity using the integral index. Materials and Methods: We examined 19 adolescent boys (mean age of 4.41±0.45 years) with obesity of the first degree (the study group). T...
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2018-03-01
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| Series: | International Journal of Biomedicine |
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| Online Access: | http://ijbm.org/articles/IJBM_8(1)_OA5.pdf |
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| author | Marina A. Darenskaya Oksana A. Gavrilova Lyubov V. Rychkova Olga V. Kravtsova Lyudmila A. Grebenkina Elena V. Osipova Sergey I. Kolesnikov |
| author_facet | Marina A. Darenskaya Oksana A. Gavrilova Lyubov V. Rychkova Olga V. Kravtsova Lyudmila A. Grebenkina Elena V. Osipova Sergey I. Kolesnikov |
| author_sort | Marina A. Darenskaya |
| collection | DOAJ |
| description | The aim of this research was to assess lipid peroxidation (LPO) and antioxidative defense (AOD) changes in adolescent boys with obesity using the integral index.
Materials and Methods: We examined 19 adolescent boys (mean age of 4.41±0.45 years) with obesity of the first degree (the study group). The control group included 23 healthy boys (mean age of 15.12±0.32 years). The study included the collection of anamnestic data, physical examination, and anthropometric data analysis (body weight (BW), height, waist circumference (WC), hip circumference (HC), and body mass index (BMI)). Laboratory analysis included an assessment of the levels of total cholesterol, triglycerides, HDL, LDL, and blood glucose, as well as the intensity of LPO and AOD in blood plasma and primary and secondary products of LPO. To measure the intensity of OS, the oxidative stress index (OSi) was calculated (the ratio of the LPO-AOD system indicators in the study group to average indicators in the control group).
Results: We found a statistically significant increase in BW, BMI, SDS BMI, WC, and HC in the study group compared to the control group. The obese patients had higher values of blood glucose, total cholesterol, triglycerides and LDL compared to the control group. In the study group, we found a significant decrease in the concentration of diene conjugates and an increase in the level of ketodienes and conjugated trienes. The values of α-tocopherol and retinol, and SOD activity were significantly decreased in the study group compared to the control group. There were no statistically significant changes in total antioxidant activity and glutathione status components. According to the data received, the OSi level in the group of obese patients increased approximately 7 times, which confirms the results on the development of antioxidant insufficiency in this pathology. |
| first_indexed | 2024-12-23T04:00:27Z |
| format | Article |
| id | doaj.art-32b9bc29d6c94385afb749efc4f31f35 |
| institution | Directory Open Access Journal |
| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-23T04:00:27Z |
| publishDate | 2018-03-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-32b9bc29d6c94385afb749efc4f31f352022-12-21T18:00:44ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292018-03-0181374110.21103/Article8(1)_OA5The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral IndexMarina A. Darenskaya0Oksana A. Gavrilova1Lyubov V. Rychkova2Olga V. Kravtsova3Lyudmila A. Grebenkina4Elena V. Osipova5Sergey I. Kolesnikov6Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationScientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian Federation; Irkutsk State University Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, the Russian FederationThe aim of this research was to assess lipid peroxidation (LPO) and antioxidative defense (AOD) changes in adolescent boys with obesity using the integral index. Materials and Methods: We examined 19 adolescent boys (mean age of 4.41±0.45 years) with obesity of the first degree (the study group). The control group included 23 healthy boys (mean age of 15.12±0.32 years). The study included the collection of anamnestic data, physical examination, and anthropometric data analysis (body weight (BW), height, waist circumference (WC), hip circumference (HC), and body mass index (BMI)). Laboratory analysis included an assessment of the levels of total cholesterol, triglycerides, HDL, LDL, and blood glucose, as well as the intensity of LPO and AOD in blood plasma and primary and secondary products of LPO. To measure the intensity of OS, the oxidative stress index (OSi) was calculated (the ratio of the LPO-AOD system indicators in the study group to average indicators in the control group). Results: We found a statistically significant increase in BW, BMI, SDS BMI, WC, and HC in the study group compared to the control group. The obese patients had higher values of blood glucose, total cholesterol, triglycerides and LDL compared to the control group. In the study group, we found a significant decrease in the concentration of diene conjugates and an increase in the level of ketodienes and conjugated trienes. The values of α-tocopherol and retinol, and SOD activity were significantly decreased in the study group compared to the control group. There were no statistically significant changes in total antioxidant activity and glutathione status components. According to the data received, the OSi level in the group of obese patients increased approximately 7 times, which confirms the results on the development of antioxidant insufficiency in this pathology.http://ijbm.org/articles/IJBM_8(1)_OA5.pdflipid peroxidationantioxidative defenseoxidative stress indexobesityadolescent boys |
| spellingShingle | Marina A. Darenskaya Oksana A. Gavrilova Lyubov V. Rychkova Olga V. Kravtsova Lyudmila A. Grebenkina Elena V. Osipova Sergey I. Kolesnikov The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index International Journal of Biomedicine lipid peroxidation antioxidative defense oxidative stress index obesity adolescent boys |
| title | The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index |
| title_full | The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index |
| title_fullStr | The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index |
| title_full_unstemmed | The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index |
| title_short | The Assessment of Oxidative Stress Intensity in Adolescents with Obesity by the Integral Index |
| title_sort | assessment of oxidative stress intensity in adolescents with obesity by the integral index |
| topic | lipid peroxidation antioxidative defense oxidative stress index obesity adolescent boys |
| url | http://ijbm.org/articles/IJBM_8(1)_OA5.pdf |
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