Inactivation of farR Causes High Rhodomyrtone Resistance and Increased Pathogenicity in Staphylococcus aureus

Inactivation of farR Causes High Rhodomyrtone Resistance and Increased Pathogenicity in Staphylococcus aureus

Rhodomyrtone (Rom) is an acylphloroglucinol antibiotic originally isolated from leaves of Rhodomyrtus tomentosa. Rom targets the bacterial membrane and is active against a wide range of Gram-positive bacteria but the exact mode of action remains obscure. Here we isolated and characterized a spontane...

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Bibliographic Details
Main Authors: Minh-Thu Nguyen, Jongkon Saising, Paula Maria Tribelli, Mulugeta Nega, Seydina M. Diene, Patrice François, Jacques Schrenzel, Cathrin Spröer, Boyke Bunk, Patrick Ebner, Tobias Hertlein, Nimerta Kumari, Thomas Härtner, Dorothee Wistuba, Supayang P. Voravuthikunchai, Ulrike Mäder, Knut Ohlsen, Friedrich Götz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Microbiology
Subjects:
antibiotic
Gram-positive bacteria
rhodomyrtone
Staphylococcus
membrane active
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01157/full

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