Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★
Microtubule-targeted agents (MTAs), widely used in chemotherapy, are molecules that are able to block cancer cell migration and division. Their effect on microtubule (MT) dynamic instability is measured by their influence on observable parameters of MT dynamics such as growth speed, time-based catas...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2018-01-01
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| Series: | ESAIM: Proceedings and Surveys |
| Online Access: | https://doi.org/10.1051/proc/201862186201 |
| _version_ | 1797966747096055808 |
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| author | Barlukova Ayuna Honoré Stéphane Hubert Florence |
| author_facet | Barlukova Ayuna Honoré Stéphane Hubert Florence |
| author_sort | Barlukova Ayuna |
| collection | DOAJ |
| description | Microtubule-targeted agents (MTAs), widely used in chemotherapy, are molecules that are able to block cancer cell migration and division. Their effect on microtubule (MT) dynamic instability is measured by their influence on observable parameters of MT dynamics such as growth speed, time-based catastrophe frequency, time-based rescue fre- quency, etc. In this paper, we propose a new mathematical model that is able to reproduce MT dynamics with an appropriate estimation of the main observable parameters. Using the experimental data on paclitaxel effect in presence of EB proteins, we fitted param- eters of the model from several drug concentrations. It enable us to understand which non-observable model parameters are able to reproduce the effect of MTAs and thus to highlight a new potential mechanism of action associated with MTAs effect in presence of EB protein. |
| first_indexed | 2024-04-11T02:19:09Z |
| format | Article |
| id | doaj.art-32bbefb44522404581d9d98086ded2b0 |
| institution | Directory Open Access Journal |
| issn | 2267-3059 |
| language | English |
| last_indexed | 2024-04-11T02:19:09Z |
| publishDate | 2018-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | ESAIM: Proceedings and Surveys |
| spelling | doaj.art-32bbefb44522404581d9d98086ded2b02023-01-03T00:10:31ZengEDP SciencesESAIM: Proceedings and Surveys2267-30592018-01-016211610.1051/proc/201862186201proc_esaim2018_186201Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★Barlukova AyunaHonoré StéphaneHubert FlorenceMicrotubule-targeted agents (MTAs), widely used in chemotherapy, are molecules that are able to block cancer cell migration and division. Their effect on microtubule (MT) dynamic instability is measured by their influence on observable parameters of MT dynamics such as growth speed, time-based catastrophe frequency, time-based rescue fre- quency, etc. In this paper, we propose a new mathematical model that is able to reproduce MT dynamics with an appropriate estimation of the main observable parameters. Using the experimental data on paclitaxel effect in presence of EB proteins, we fitted param- eters of the model from several drug concentrations. It enable us to understand which non-observable model parameters are able to reproduce the effect of MTAs and thus to highlight a new potential mechanism of action associated with MTAs effect in presence of EB protein.https://doi.org/10.1051/proc/201862186201 |
| spellingShingle | Barlukova Ayuna Honoré Stéphane Hubert Florence Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★ ESAIM: Proceedings and Surveys |
| title | Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★ |
| title_full | Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★ |
| title_fullStr | Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★ |
| title_full_unstemmed | Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★ |
| title_short | Mathematical Modeling of Effect Of Microtubule-Targeted Agents On Microtubule Dynamic Instability★ |
| title_sort | mathematical modeling of effect of microtubule targeted agents on microtubule dynamic instability★ |
| url | https://doi.org/10.1051/proc/201862186201 |
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