Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis

Depleting Cationic Lipids Involved in Antimicrobial Resistance Drives Adaptive Lipid Remodeling in Enterococcus faecalis

ABSTRACT The bacterial cell membrane is an interface for cell envelope synthesis, protein secretion, virulence factor assembly, and a target for host cationic antimicrobial peptides (CAMPs). To resist CAMP killing, several Gram-positive pathogens encode the multiple peptide resistance factor (MprF)...

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Bibliographic Details
Main Authors: Rafi Rashid, Zeus Jaren Nair, Dominic Ming Hao Chia, Kelvin Kian Long Chong, Amaury Cazenave Gassiot, Stewart A. Morley, Doug K. Allen, Swaine L. Chen, Shu Sin Chng, Markus R. Wenk, Kimberly A. Kline
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
multiple peptide resistance factor (MprF)
lysyl-phosphatidylglycerol (L-PG)
cationic antimicrobial peptides (CAMPs)
lipid homeostasis
lipid metabolism
adaptive remodeling
Online Access:https://journals.asm.org/doi/10.1128/mbio.03073-22

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