Design of an adaptive randomized clinical trial of intravenous citrulline for sickle cell pain crisis in the emergency department

Design of an adaptive randomized clinical trial of intravenous citrulline for sickle cell pain crisis in the emergency department

Background: Vaso-occlusive pain crisis (VOC) is the most frequent cause for Emergency Department (ED) visits and hospital admissions for patients with sickle cell disease (SCD). Nitric oxide plays a critical role in the pathogenesis of vaso-occlusion. The amino acid, citrulline, is the main endothel...

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Main Authors: S. Majumdar, K.W. McKinley, J. Chamberlain, B. Thomas, S. Margulies, R.S. Nickel, D.S. Darbari, A. Campbell, C. Berul, M. Summar, G. Kalsi
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Contemporary Clinical Trials Communications
Online Access:http://www.sciencedirect.com/science/article/pii/S2451865423000236

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http://www.sciencedirect.com/science/article/pii/S2451865423000236

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