Design of an adaptive randomized clinical trial of intravenous citrulline for sickle cell pain crisis in the emergency department
Background: Vaso-occlusive pain crisis (VOC) is the most frequent cause for Emergency Department (ED) visits and hospital admissions for patients with sickle cell disease (SCD). Nitric oxide plays a critical role in the pathogenesis of vaso-occlusion. The amino acid, citrulline, is the main endothel...
Main Authors: | S. Majumdar, K.W. McKinley, J. Chamberlain, B. Thomas, S. Margulies, R.S. Nickel, D.S. Darbari, A. Campbell, C. Berul, M. Summar, G. Kalsi |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-04-01
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Series: | Contemporary Clinical Trials Communications |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865423000236 |
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