Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells.
Alopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low efficacy and potentially undesirable side effects. We have identified a new function for valproic acid (VPA), a GSK3β inhibitor that activates the Wnt/β-caten...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3323655?pdf=render |
| _version_ | 1811275060684521472 |
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| author | Soung-Hoon Lee Juyong Yoon Seung Ho Shin Muhamad Zahoor Hyoung Jun Kim Phil June Park Won-Seok Park Do Sik Min Hyun-Yi Kim Kang-Yell Choi |
| author_facet | Soung-Hoon Lee Juyong Yoon Seung Ho Shin Muhamad Zahoor Hyoung Jun Kim Phil June Park Won-Seok Park Do Sik Min Hyun-Yi Kim Kang-Yell Choi |
| author_sort | Soung-Hoon Lee |
| collection | DOAJ |
| description | Alopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low efficacy and potentially undesirable side effects. We have identified a new function for valproic acid (VPA), a GSK3β inhibitor that activates the Wnt/β-catenin pathway, to promote hair re-growth in vitro and in vivo.Topical application of VPA to male C3H mice critically stimulated hair re-growth and induced terminally differentiated epidermal markers such as filaggrin and loricrin, and the dermal papilla marker alkaline phosphatase (ALP). VPA induced ALP in human dermal papilla cells by up-regulating the Wnt/β-catenin pathway, whereas minoxidil (MNX), a drug commonly used to treat alopecia, did not significantly affect the Wnt/β-catenin pathway. VPA analogs and other GSK3β inhibitors that activate the Wnt/β-catenin pathway such as 4-phenyl butyric acid, LiCl, and BeCl(2) also exhibited hair growth-promoting activities in vivo. Importantly, VPA, but not MNX, successfully stimulate hair growth in the wounds of C3H mice.Our findings indicate that small molecules that activate the Wnt/β-catenin pathway, such as VPA, can potentially be developed as drugs to stimulate hair re-growth. |
| first_indexed | 2024-04-12T23:31:20Z |
| format | Article |
| id | doaj.art-32c00e6e4ca94daab2b76c668a8d27ca |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T23:31:20Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-32c00e6e4ca94daab2b76c668a8d27ca2022-12-22T03:12:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0174e3415210.1371/journal.pone.0034152Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells.Soung-Hoon LeeJuyong YoonSeung Ho ShinMuhamad ZahoorHyoung Jun KimPhil June ParkWon-Seok ParkDo Sik MinHyun-Yi KimKang-Yell ChoiAlopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low efficacy and potentially undesirable side effects. We have identified a new function for valproic acid (VPA), a GSK3β inhibitor that activates the Wnt/β-catenin pathway, to promote hair re-growth in vitro and in vivo.Topical application of VPA to male C3H mice critically stimulated hair re-growth and induced terminally differentiated epidermal markers such as filaggrin and loricrin, and the dermal papilla marker alkaline phosphatase (ALP). VPA induced ALP in human dermal papilla cells by up-regulating the Wnt/β-catenin pathway, whereas minoxidil (MNX), a drug commonly used to treat alopecia, did not significantly affect the Wnt/β-catenin pathway. VPA analogs and other GSK3β inhibitors that activate the Wnt/β-catenin pathway such as 4-phenyl butyric acid, LiCl, and BeCl(2) also exhibited hair growth-promoting activities in vivo. Importantly, VPA, but not MNX, successfully stimulate hair growth in the wounds of C3H mice.Our findings indicate that small molecules that activate the Wnt/β-catenin pathway, such as VPA, can potentially be developed as drugs to stimulate hair re-growth.http://europepmc.org/articles/PMC3323655?pdf=render |
| spellingShingle | Soung-Hoon Lee Juyong Yoon Seung Ho Shin Muhamad Zahoor Hyoung Jun Kim Phil June Park Won-Seok Park Do Sik Min Hyun-Yi Kim Kang-Yell Choi Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. PLoS ONE |
| title | Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. |
| title_full | Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. |
| title_fullStr | Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. |
| title_full_unstemmed | Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. |
| title_short | Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. |
| title_sort | valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells |
| url | http://europepmc.org/articles/PMC3323655?pdf=render |
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