Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study
BackgroundAging is a significant risk factor for many neurodegenerative diseases and neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere length (TL), and epigenetic aging clock acceleration are commonly used biological aging proxy indicators. This study aims...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1321246/full |
| _version_ | 1797386558110695424 |
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| author | Zhiyun Zhang Ningfang Liu Xuyang Pan Chuyi Zhang Yifan Yang Xinyun Li Ying Shao |
| author_facet | Zhiyun Zhang Ningfang Liu Xuyang Pan Chuyi Zhang Yifan Yang Xinyun Li Ying Shao |
| author_sort | Zhiyun Zhang |
| collection | DOAJ |
| description | BackgroundAging is a significant risk factor for many neurodegenerative diseases and neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere length (TL), and epigenetic aging clock acceleration are commonly used biological aging proxy indicators. This study aims to comprehensively explore potential relationships between biological aging and neurodegenerative diseases and neurological tumors by integrating various biological aging proxy indicators, employing Mendelian randomization (MR) analysis.MethodsTwo-sample bidirectional MR analyses were conducted using genome-wide association study (GWAS) data. Summary statistics for various neurodegenerative diseases and neurological tumors, along with biological aging proxy indicators, were obtained from extensive meta-analyses of GWAS. Genetic single-nucleotide polymorphisms (SNPs) associated with the exposures were used as instrumental variables, assessing causal relationships between three neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis), two benign neurological tumors (vestibular schwannoma and meningioma), one malignant neurological tumor (glioma), and four biological aging indicators (frailty index, facial aging, TL, and epigenetic aging clock acceleration). Sensitivity analyses were also performed.ResultsOur analysis revealed that genetically predicted longer TL reduces the risk of Alzheimer’s disease but increases the risk of vestibular schwannoma and glioma (All Glioma, GBM, non-GBM). In addition, there is a suggestive causal relationship between some diseases (PD and GBM) and DNA methylation GrimAge acceleration. Causal relationships between biological aging proxy indicators and other neurodegenerative diseases and neurological tumors were not observed.ConclusionBuilding upon prior investigations into the causal relationships between telomeres and neurodegenerative diseases and neurological tumors, our study validates these findings using larger GWAS data and demonstrates, for the first time, that Parkinson’s disease and GBM may promote epigenetic age acceleration. Our research provides new insights and evidence into the causal relationships between biological aging and the risk of neurodegenerative diseases and neurological tumors. |
| first_indexed | 2024-03-08T22:12:08Z |
| format | Article |
| id | doaj.art-32c044e1febb47e18d23d87bce107246 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-08T22:12:08Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-32c044e1febb47e18d23d87bce1072462023-12-19T06:11:26ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-12-011710.3389/fnins.2023.13212461321246Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization studyZhiyun Zhang0Ningfang Liu1Xuyang Pan2Chuyi Zhang3Yifan Yang4Xinyun Li5Ying Shao6Department of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, ChinaDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, ChinaThe Second Hospital of Jilin University, Changchun, Jilin, ChinaInfection Department, The First Bethune Hospital of Jilin University, Changchun, ChinaDepartment of Plastic and Reconstructive Surgery, The First Hospital of Jilin University, Changchun, ChinaBackgroundAging is a significant risk factor for many neurodegenerative diseases and neurological tumors. Previous studies indicate that the frailty index, facial aging, telomere length (TL), and epigenetic aging clock acceleration are commonly used biological aging proxy indicators. This study aims to comprehensively explore potential relationships between biological aging and neurodegenerative diseases and neurological tumors by integrating various biological aging proxy indicators, employing Mendelian randomization (MR) analysis.MethodsTwo-sample bidirectional MR analyses were conducted using genome-wide association study (GWAS) data. Summary statistics for various neurodegenerative diseases and neurological tumors, along with biological aging proxy indicators, were obtained from extensive meta-analyses of GWAS. Genetic single-nucleotide polymorphisms (SNPs) associated with the exposures were used as instrumental variables, assessing causal relationships between three neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis), two benign neurological tumors (vestibular schwannoma and meningioma), one malignant neurological tumor (glioma), and four biological aging indicators (frailty index, facial aging, TL, and epigenetic aging clock acceleration). Sensitivity analyses were also performed.ResultsOur analysis revealed that genetically predicted longer TL reduces the risk of Alzheimer’s disease but increases the risk of vestibular schwannoma and glioma (All Glioma, GBM, non-GBM). In addition, there is a suggestive causal relationship between some diseases (PD and GBM) and DNA methylation GrimAge acceleration. Causal relationships between biological aging proxy indicators and other neurodegenerative diseases and neurological tumors were not observed.ConclusionBuilding upon prior investigations into the causal relationships between telomeres and neurodegenerative diseases and neurological tumors, our study validates these findings using larger GWAS data and demonstrates, for the first time, that Parkinson’s disease and GBM may promote epigenetic age acceleration. Our research provides new insights and evidence into the causal relationships between biological aging and the risk of neurodegenerative diseases and neurological tumors.https://www.frontiersin.org/articles/10.3389/fnins.2023.1321246/fullneurodegenerative diseasesneurological tumorsbiological agingbidirectional Mendelian randomization studygenome-wide association study (GWAS) |
| spellingShingle | Zhiyun Zhang Ningfang Liu Xuyang Pan Chuyi Zhang Yifan Yang Xinyun Li Ying Shao Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study Frontiers in Neuroscience neurodegenerative diseases neurological tumors biological aging bidirectional Mendelian randomization study genome-wide association study (GWAS) |
| title | Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study |
| title_full | Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study |
| title_fullStr | Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study |
| title_full_unstemmed | Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study |
| title_short | Assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging: a bidirectional Mendelian randomization study |
| title_sort | assessing causal associations between neurodegenerative diseases and neurological tumors with biological aging a bidirectional mendelian randomization study |
| topic | neurodegenerative diseases neurological tumors biological aging bidirectional Mendelian randomization study genome-wide association study (GWAS) |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1321246/full |
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