Marine-Derived Angiogenesis Inhibitors for Cancer Therapy
Angiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many marine-derived natural products and their analogues have been reported to show antiangiogenic activities. Compared with the drugs in the clinic, these agents display interesting characteristics, including dive...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-03-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/11/3/903 |
| _version_ | 1811263935833178112 |
|---|---|
| author | Ying-Qing Wang Ze-Hong Miao |
| author_facet | Ying-Qing Wang Ze-Hong Miao |
| author_sort | Ying-Qing Wang |
| collection | DOAJ |
| description | Angiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many marine-derived natural products and their analogues have been reported to show antiangiogenic activities. Compared with the drugs in the clinic, these agents display interesting characteristics, including diverse sources, unique chemical structures, special modes of action, and distinct activity and toxicity profiles. This review will first provide an overview of the current marine-derived angiogenesis inhibitors based on their primary targets and/or mechanisms of action. Then, the marine-derived antiangiogenic protein kinase inhibitors will be focused on. And finally, the clinical trials of the marine-derived antiangiogenic agents will be discussed, with special emphasis on their application potentials, problems and possible coping strategies in their future development as anticancer drugs. |
| first_indexed | 2024-04-12T19:54:06Z |
| format | Article |
| id | doaj.art-32c046ccea194c2a8bddf5cf5fb6439b |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-12T19:54:06Z |
| publishDate | 2013-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-32c046ccea194c2a8bddf5cf5fb6439b2022-12-22T03:18:42ZengMDPI AGMarine Drugs1660-33972013-03-0111390393310.3390/md11030903Marine-Derived Angiogenesis Inhibitors for Cancer TherapyYing-Qing WangZe-Hong MiaoAngiogenesis inhibitors have been successfully used for cancer therapy in the clinic. Many marine-derived natural products and their analogues have been reported to show antiangiogenic activities. Compared with the drugs in the clinic, these agents display interesting characteristics, including diverse sources, unique chemical structures, special modes of action, and distinct activity and toxicity profiles. This review will first provide an overview of the current marine-derived angiogenesis inhibitors based on their primary targets and/or mechanisms of action. Then, the marine-derived antiangiogenic protein kinase inhibitors will be focused on. And finally, the clinical trials of the marine-derived antiangiogenic agents will be discussed, with special emphasis on their application potentials, problems and possible coping strategies in their future development as anticancer drugs.http://www.mdpi.com/1660-3397/11/3/903marine natural productsangiogenesisprotein kinasecancer therapy |
| spellingShingle | Ying-Qing Wang Ze-Hong Miao Marine-Derived Angiogenesis Inhibitors for Cancer Therapy Marine Drugs marine natural products angiogenesis protein kinase cancer therapy |
| title | Marine-Derived Angiogenesis Inhibitors for Cancer Therapy |
| title_full | Marine-Derived Angiogenesis Inhibitors for Cancer Therapy |
| title_fullStr | Marine-Derived Angiogenesis Inhibitors for Cancer Therapy |
| title_full_unstemmed | Marine-Derived Angiogenesis Inhibitors for Cancer Therapy |
| title_short | Marine-Derived Angiogenesis Inhibitors for Cancer Therapy |
| title_sort | marine derived angiogenesis inhibitors for cancer therapy |
| topic | marine natural products angiogenesis protein kinase cancer therapy |
| url | http://www.mdpi.com/1660-3397/11/3/903 |
| work_keys_str_mv | AT yingqingwang marinederivedangiogenesisinhibitorsforcancertherapy AT zehongmiao marinederivedangiogenesisinhibitorsforcancertherapy |