Epigenetics in Congenital Heart Disease
Embryonic heart development is an intricate process that mainly involves morphogens, transcription factors, and cardiac genes. The precise spatiotemporal expression of these genes during different developmental stages underlies normal heart development. Thus, mutation or aberrant expression of these...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-04-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.025163 |
| _version_ | 1797849623726915584 |
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| author | Guanglei Wang Bingbing Wang Peixin Yang |
| author_facet | Guanglei Wang Bingbing Wang Peixin Yang |
| author_sort | Guanglei Wang |
| collection | DOAJ |
| description | Embryonic heart development is an intricate process that mainly involves morphogens, transcription factors, and cardiac genes. The precise spatiotemporal expression of these genes during different developmental stages underlies normal heart development. Thus, mutation or aberrant expression of these genes may lead to congenital heart disease (CHD). However, evidence demonstrates that the mutation of genes accounts for only a small portion of CHD cases, whereas the aberrant expression regulated by epigenetic modification plays a predominant role in the pathogenesis of CHD. In this review, we provide essential knowledge on the aberrant epigenetic modification involved in the pathogenesis of CHD. Then, we discuss recent advances in the identification of novel epigenetic biomarkers. Last, we highlight the epigenetic roles in some adverse intrauterine environment‐related CHD, which may help the prevention, diagnosis, and treatment of these kinds of CHD. |
| first_indexed | 2024-04-09T18:47:04Z |
| format | Article |
| id | doaj.art-32c249b8e9874fbbbfef1e4e2555eb09 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T18:47:04Z |
| publishDate | 2022-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-32c249b8e9874fbbbfef1e4e2555eb092023-04-10T11:57:34ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-04-0111710.1161/JAHA.121.025163Epigenetics in Congenital Heart DiseaseGuanglei Wang0Bingbing Wang1Peixin Yang2Department of Obstetrics, Gynecology, & Reproductive Sciences University of Maryland School of Medicine Baltimore MDDepartment of Obstetrics, Gynecology, & Reproductive Sciences University of Maryland School of Medicine Baltimore MDDepartment of Obstetrics, Gynecology, & Reproductive Sciences University of Maryland School of Medicine Baltimore MDEmbryonic heart development is an intricate process that mainly involves morphogens, transcription factors, and cardiac genes. The precise spatiotemporal expression of these genes during different developmental stages underlies normal heart development. Thus, mutation or aberrant expression of these genes may lead to congenital heart disease (CHD). However, evidence demonstrates that the mutation of genes accounts for only a small portion of CHD cases, whereas the aberrant expression regulated by epigenetic modification plays a predominant role in the pathogenesis of CHD. In this review, we provide essential knowledge on the aberrant epigenetic modification involved in the pathogenesis of CHD. Then, we discuss recent advances in the identification of novel epigenetic biomarkers. Last, we highlight the epigenetic roles in some adverse intrauterine environment‐related CHD, which may help the prevention, diagnosis, and treatment of these kinds of CHD.https://www.ahajournals.org/doi/10.1161/JAHA.121.025163biomarkerscardiac developmentcongenital heart diseaseepigenetics |
| spellingShingle | Guanglei Wang Bingbing Wang Peixin Yang Epigenetics in Congenital Heart Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease biomarkers cardiac development congenital heart disease epigenetics |
| title | Epigenetics in Congenital Heart Disease |
| title_full | Epigenetics in Congenital Heart Disease |
| title_fullStr | Epigenetics in Congenital Heart Disease |
| title_full_unstemmed | Epigenetics in Congenital Heart Disease |
| title_short | Epigenetics in Congenital Heart Disease |
| title_sort | epigenetics in congenital heart disease |
| topic | biomarkers cardiac development congenital heart disease epigenetics |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.025163 |
| work_keys_str_mv | AT guangleiwang epigeneticsincongenitalheartdisease AT bingbingwang epigeneticsincongenitalheartdisease AT peixinyang epigeneticsincongenitalheartdisease |