Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT
Abstract Background The aim of this study was to explore application value of iodine concentration from dual-energy spectral computed tomography (DESCT) in preoperative prediction of lymphovascular tumor thrombus in patients with colorectal cancer (CRC). Methods We finally retrospectively analyzed 5...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-08-01
|
| Series: | BMC Medical Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12880-023-01060-z |
| _version_ | 1827632691056476160 |
|---|---|
| author | Xiang Yuan Xin Quan Xiao-ling Che Lu-Lu Xu Chun-mei Yang Xiao-di Zhang Jian Shu |
| author_facet | Xiang Yuan Xin Quan Xiao-ling Che Lu-Lu Xu Chun-mei Yang Xiao-di Zhang Jian Shu |
| author_sort | Xiang Yuan |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to explore application value of iodine concentration from dual-energy spectral computed tomography (DESCT) in preoperative prediction of lymphovascular tumor thrombus in patients with colorectal cancer (CRC). Methods We finally retrospectively analyzed 50 patients with CRC who underwent abdominal DESCT before receiving any preoperative treatment and underwent surgery to obtain pathological specimens which were stained with hematoxylin-eosin (HE) staining. According to the presence of cancer cell nests in blood vessels and lymphatic vessels, the subjects were divided into the positive group and negative group of lymphovascular tumor thrombus. Two radiologists independently measured the normalized iodine concentration (NIC) values, effective atomic number (Zeff) and CT values of virtual monochromatic images (VMIs) at 40–90 keV of the primary tumors in the arterial phase (AP) and venous phase (VP). Used SPSS 17.0 to calculate the receiver operating characteristic (ROC) curve to evaluate diagnostic value. Results The patients were divided into lymphovascular tumor thrombus positive group(n = 16) and negative group(n = 34). The values of NIC-AP and NIC-VP in the positive group were 0.17 ± 0.09, 0.51 ± 0.13, respectively. And those in the negative group were 0.15 ± 0.06, 0.43 ± 0.12, respectively. There was significant difference in NIC-VP value between the two groups (p = 0.039), but there was no significant difference in NIC-AP value (p = 0.423). The optimal threshold value of NIC-VP value for diagnosis of lymphovascular tumor thrombus was 0.364. The sensitivity was 68.8% and the specificity was 67.6%. Conclusions The NIC-VP value of DESCT can be used to predict the presence or absence of the lymphovascular tumor thrombus in CRC patients before operation, which is helpful to select the best treatment scheme and evaluate its prognosis. |
| first_indexed | 2024-03-09T14:49:07Z |
| format | Article |
| id | doaj.art-32c254d0d0844f1889663b30701d0e78 |
| institution | Directory Open Access Journal |
| issn | 1471-2342 |
| language | English |
| last_indexed | 2024-03-09T14:49:07Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Imaging |
| spelling | doaj.art-32c254d0d0844f1889663b30701d0e782023-11-26T14:35:04ZengBMCBMC Medical Imaging1471-23422023-08-012311710.1186/s12880-023-01060-zPreoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CTXiang Yuan0Xin Quan1Xiao-ling Che2Lu-Lu Xu3Chun-mei Yang4Xiao-di Zhang5Jian Shu6Department of Radiology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Radiology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Radiology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Radiology, The Affiliated Hospital of Southwest Medical UniversityDepartment of Radiology, The Affiliated Hospital of Southwest Medical UniversityPhilips HealthcareDepartment of Radiology, The Affiliated Hospital of Southwest Medical UniversityAbstract Background The aim of this study was to explore application value of iodine concentration from dual-energy spectral computed tomography (DESCT) in preoperative prediction of lymphovascular tumor thrombus in patients with colorectal cancer (CRC). Methods We finally retrospectively analyzed 50 patients with CRC who underwent abdominal DESCT before receiving any preoperative treatment and underwent surgery to obtain pathological specimens which were stained with hematoxylin-eosin (HE) staining. According to the presence of cancer cell nests in blood vessels and lymphatic vessels, the subjects were divided into the positive group and negative group of lymphovascular tumor thrombus. Two radiologists independently measured the normalized iodine concentration (NIC) values, effective atomic number (Zeff) and CT values of virtual monochromatic images (VMIs) at 40–90 keV of the primary tumors in the arterial phase (AP) and venous phase (VP). Used SPSS 17.0 to calculate the receiver operating characteristic (ROC) curve to evaluate diagnostic value. Results The patients were divided into lymphovascular tumor thrombus positive group(n = 16) and negative group(n = 34). The values of NIC-AP and NIC-VP in the positive group were 0.17 ± 0.09, 0.51 ± 0.13, respectively. And those in the negative group were 0.15 ± 0.06, 0.43 ± 0.12, respectively. There was significant difference in NIC-VP value between the two groups (p = 0.039), but there was no significant difference in NIC-AP value (p = 0.423). The optimal threshold value of NIC-VP value for diagnosis of lymphovascular tumor thrombus was 0.364. The sensitivity was 68.8% and the specificity was 67.6%. Conclusions The NIC-VP value of DESCT can be used to predict the presence or absence of the lymphovascular tumor thrombus in CRC patients before operation, which is helpful to select the best treatment scheme and evaluate its prognosis.https://doi.org/10.1186/s12880-023-01060-zDual-Energy spectral CTLymphovascular tumor thrombusColorectal cancerIodine concentrations |
| spellingShingle | Xiang Yuan Xin Quan Xiao-ling Che Lu-Lu Xu Chun-mei Yang Xiao-di Zhang Jian Shu Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT BMC Medical Imaging Dual-Energy spectral CT Lymphovascular tumor thrombus Colorectal cancer Iodine concentrations |
| title | Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT |
| title_full | Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT |
| title_fullStr | Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT |
| title_full_unstemmed | Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT |
| title_short | Preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual-energy spectral CT |
| title_sort | preoperative prediction of the lymphovascular tumor thrombus of colorectal cancer with the iodine concentrations from dual energy spectral ct |
| topic | Dual-Energy spectral CT Lymphovascular tumor thrombus Colorectal cancer Iodine concentrations |
| url | https://doi.org/10.1186/s12880-023-01060-z |
| work_keys_str_mv | AT xiangyuan preoperativepredictionofthelymphovasculartumorthrombusofcolorectalcancerwiththeiodineconcentrationsfromdualenergyspectralct AT xinquan preoperativepredictionofthelymphovasculartumorthrombusofcolorectalcancerwiththeiodineconcentrationsfromdualenergyspectralct AT xiaolingche preoperativepredictionofthelymphovasculartumorthrombusofcolorectalcancerwiththeiodineconcentrationsfromdualenergyspectralct AT luluxu preoperativepredictionofthelymphovasculartumorthrombusofcolorectalcancerwiththeiodineconcentrationsfromdualenergyspectralct AT chunmeiyang preoperativepredictionofthelymphovasculartumorthrombusofcolorectalcancerwiththeiodineconcentrationsfromdualenergyspectralct AT xiaodizhang preoperativepredictionofthelymphovasculartumorthrombusofcolorectalcancerwiththeiodineconcentrationsfromdualenergyspectralct AT jianshu preoperativepredictionofthelymphovasculartumorthrombusofcolorectalcancerwiththeiodineconcentrationsfromdualenergyspectralct |