Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders
Abstract Eating disorders (EDs) are syndromes with a multifactorial etiopathogenesis, involving childhood traumatic experiences, as well as biological factors. Human microbiome has been hypothesised to play a fundamental role, impacting on emotion regulation, as well as with eating behaviours throug...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38665-x |
| _version_ | 1827895268600709120 |
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| author | Giovanni Castellini Emanuele Cassioli Francesco Vitali Eleonora Rossi Cristiano Dani Giulia Melani Dario Flaccomio Martina D’Andria Mariela Mejia Monroy Andrea Galli Duccio Cavalieri Valdo Ricca Gian Luca Bartolucci Carlotta De Filippo |
| author_facet | Giovanni Castellini Emanuele Cassioli Francesco Vitali Eleonora Rossi Cristiano Dani Giulia Melani Dario Flaccomio Martina D’Andria Mariela Mejia Monroy Andrea Galli Duccio Cavalieri Valdo Ricca Gian Luca Bartolucci Carlotta De Filippo |
| author_sort | Giovanni Castellini |
| collection | DOAJ |
| description | Abstract Eating disorders (EDs) are syndromes with a multifactorial etiopathogenesis, involving childhood traumatic experiences, as well as biological factors. Human microbiome has been hypothesised to play a fundamental role, impacting on emotion regulation, as well as with eating behaviours through its metabolites such as short chain fatty acids (SCFAs). The present study investigated the interactions between psychopathology of EDs, the gut microbiome and SCFAs resulting from bacterial community metabolic activities in a population of 47 patients with Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder and in healthy controls (HCs). Bacterial gut microbiota composition differences were found between subjects with EDs and HCs, especially in association with different pathological behaviours (binge-purge vs restricting). A mediation model of early trauma and ED-specific psychopathology linked reduction of microbial diversity to a typical microbiota-derived metabolite such as butyric acid. A possible interpretation for this model might be that childhood trauma represents a risk factor for gut dysbiosis and for a stable modification of mechanisms responsible for SCFAs production, and that this dysfunctional community is inherited in the passage from childhood to adulthood. These findings might open the way to novel interventions of butyric acid-like compounds as well as faecal transplant. |
| first_indexed | 2024-03-12T22:18:37Z |
| format | Article |
| id | doaj.art-32c2a507c27a44188c2bbf61bd767509 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T22:18:37Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-32c2a507c27a44188c2bbf61bd7675092023-07-23T11:10:58ZengNature PortfolioScientific Reports2045-23222023-07-0113111510.1038/s41598-023-38665-xGut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disordersGiovanni Castellini0Emanuele Cassioli1Francesco Vitali2Eleonora Rossi3Cristiano Dani4Giulia Melani5Dario Flaccomio6Martina D’Andria7Mariela Mejia Monroy8Andrea Galli9Duccio Cavalieri10Valdo Ricca11Gian Luca Bartolucci12Carlotta De Filippo13Department of Health Sciences, University of FlorenceDepartment of Health Sciences, University of FlorenceInstitute of Agricultural Biology and Biotechnology, National Research CouncilDepartment of Health Sciences, University of FlorenceDepartment of Health Sciences, University of FlorenceDepartment of Health Sciences, University of FlorenceDepartment of Health Sciences, University of FlorenceDepartment of Health Sciences, University of FlorenceInstitute of Agricultural Biology and Biotechnology, National Research CouncilGastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of FlorenceDepartment of Biology, University of FlorenceDepartment of Health Sciences, University of FlorenceDepartment of Neurosciences, Psychology, Drug Research and Child Health, University of FlorenceInstitute of Agricultural Biology and Biotechnology, National Research CouncilAbstract Eating disorders (EDs) are syndromes with a multifactorial etiopathogenesis, involving childhood traumatic experiences, as well as biological factors. Human microbiome has been hypothesised to play a fundamental role, impacting on emotion regulation, as well as with eating behaviours through its metabolites such as short chain fatty acids (SCFAs). The present study investigated the interactions between psychopathology of EDs, the gut microbiome and SCFAs resulting from bacterial community metabolic activities in a population of 47 patients with Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder and in healthy controls (HCs). Bacterial gut microbiota composition differences were found between subjects with EDs and HCs, especially in association with different pathological behaviours (binge-purge vs restricting). A mediation model of early trauma and ED-specific psychopathology linked reduction of microbial diversity to a typical microbiota-derived metabolite such as butyric acid. A possible interpretation for this model might be that childhood trauma represents a risk factor for gut dysbiosis and for a stable modification of mechanisms responsible for SCFAs production, and that this dysfunctional community is inherited in the passage from childhood to adulthood. These findings might open the way to novel interventions of butyric acid-like compounds as well as faecal transplant.https://doi.org/10.1038/s41598-023-38665-x |
| spellingShingle | Giovanni Castellini Emanuele Cassioli Francesco Vitali Eleonora Rossi Cristiano Dani Giulia Melani Dario Flaccomio Martina D’Andria Mariela Mejia Monroy Andrea Galli Duccio Cavalieri Valdo Ricca Gian Luca Bartolucci Carlotta De Filippo Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders Scientific Reports |
| title | Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders |
| title_full | Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders |
| title_fullStr | Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders |
| title_full_unstemmed | Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders |
| title_short | Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders |
| title_sort | gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders |
| url | https://doi.org/10.1038/s41598-023-38665-x |
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