Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis
Abstract Background The existing literature on the association between BDNF protein levels and endometriosis presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and evaluate the possible relationship between BDNF protein levels and endome...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Women's Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12905-023-02877-0 |
| _version_ | 1797355493523456000 |
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| author | Kyana Jafarabady Arman Shafiee Razman Arabzadeh Bahri Ida Mohammadi Mohammad javad Amini Shahryar Rajai Diba Akbarzadeh Faeze Soltani Abhari Emad Movahed Soraya Parvari Mahmood Bakhtiyari |
| author_facet | Kyana Jafarabady Arman Shafiee Razman Arabzadeh Bahri Ida Mohammadi Mohammad javad Amini Shahryar Rajai Diba Akbarzadeh Faeze Soltani Abhari Emad Movahed Soraya Parvari Mahmood Bakhtiyari |
| author_sort | Kyana Jafarabady |
| collection | DOAJ |
| description | Abstract Background The existing literature on the association between BDNF protein levels and endometriosis presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and evaluate the possible relationship between BDNF protein levels and endometriosis. Methods Electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) were used to conduct a comprehensive literature search from inception to June 2023. The search strategy included relevant keywords and medical subject headings (MeSH) terms related to BDNF, endometriosis, and protein levels. A random-effects model was used for the meta-analysis, and to explore heterogeneity subgroup analyses were performed. funnel plots and statistical tests were used for assessing the publication bias. Results A total of 12 studies were included. The pooled standardized mean difference (SMD) of BDNF levels between women with endometriosis and controls was 0.87 (95% confidence interval [CI] 0.34 to 1.39, p = 0.001; I2 = 93%). The results showed that blood levels of BDNF are significantly higher in endometriosis patients (SMD: 1.13 95% CI 0.54 to 1.73, p = 0.0002; I2 = 93%). No significant publication bias was observed based on the results of Egger’s regression test ((p = 0.15). Conclusion This study revealed a significant difference between patients diagnosed with endometriosis and healthy control in the level of BDNF. The results indicate that women with endometriosis have higher levels of BDNF. Further studies are needed to be undertaken to investigate the role of BDNF in endometriosis pathophysiology and the diagnostic value of BDNF in endometriosis. |
| first_indexed | 2024-03-08T14:12:58Z |
| format | Article |
| id | doaj.art-32c50b92727f47dcab6275c4938ef601 |
| institution | Directory Open Access Journal |
| issn | 1472-6874 |
| language | English |
| last_indexed | 2024-03-08T14:12:58Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Women's Health |
| spelling | doaj.art-32c50b92727f47dcab6275c4938ef6012024-01-14T12:35:01ZengBMCBMC Women's Health1472-68742024-01-012411910.1186/s12905-023-02877-0Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysisKyana Jafarabady0Arman Shafiee1Razman Arabzadeh Bahri2Ida Mohammadi3Mohammad javad Amini4Shahryar Rajai5Diba Akbarzadeh6Faeze Soltani Abhari7Emad Movahed8Soraya Parvari9Mahmood Bakhtiyari10Student Research Committee, School of Medicine, Alborz University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesStudent Research Committee, School of Medicine, Alborz University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesSchool of Medicine, Shahid Beheshti University of Medical SciencesDepartment of Psychiatry and Mental Health, Alborz University of Medical SciencesDental Reaserch Center, Faculty of Dentistry, Islamic Azad University of Medical SciencesDepartment of Anatomical Sciences, School of Medicine, Alborz University of Medical SciencesNon-Communicable Diseases Research Center, Alborz University of Medical SciencesAbstract Background The existing literature on the association between BDNF protein levels and endometriosis presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and evaluate the possible relationship between BDNF protein levels and endometriosis. Methods Electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) were used to conduct a comprehensive literature search from inception to June 2023. The search strategy included relevant keywords and medical subject headings (MeSH) terms related to BDNF, endometriosis, and protein levels. A random-effects model was used for the meta-analysis, and to explore heterogeneity subgroup analyses were performed. funnel plots and statistical tests were used for assessing the publication bias. Results A total of 12 studies were included. The pooled standardized mean difference (SMD) of BDNF levels between women with endometriosis and controls was 0.87 (95% confidence interval [CI] 0.34 to 1.39, p = 0.001; I2 = 93%). The results showed that blood levels of BDNF are significantly higher in endometriosis patients (SMD: 1.13 95% CI 0.54 to 1.73, p = 0.0002; I2 = 93%). No significant publication bias was observed based on the results of Egger’s regression test ((p = 0.15). Conclusion This study revealed a significant difference between patients diagnosed with endometriosis and healthy control in the level of BDNF. The results indicate that women with endometriosis have higher levels of BDNF. Further studies are needed to be undertaken to investigate the role of BDNF in endometriosis pathophysiology and the diagnostic value of BDNF in endometriosis.https://doi.org/10.1186/s12905-023-02877-0EndometriosisBrain-derived neurotrophic factorBDNF |
| spellingShingle | Kyana Jafarabady Arman Shafiee Razman Arabzadeh Bahri Ida Mohammadi Mohammad javad Amini Shahryar Rajai Diba Akbarzadeh Faeze Soltani Abhari Emad Movahed Soraya Parvari Mahmood Bakhtiyari Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis BMC Women's Health Endometriosis Brain-derived neurotrophic factor BDNF |
| title | Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis |
| title_full | Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis |
| title_fullStr | Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis |
| title_full_unstemmed | Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis |
| title_short | Brain-derived neurotrophic factor (BDNF) as a potential marker of endometriosis: a systematic review and meta-analysis |
| title_sort | brain derived neurotrophic factor bdnf as a potential marker of endometriosis a systematic review and meta analysis |
| topic | Endometriosis Brain-derived neurotrophic factor BDNF |
| url | https://doi.org/10.1186/s12905-023-02877-0 |
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