The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics
Abstract Introduction Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. Methods Community‐dwelling Mexican Americans and non‐Hispa...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12202 |
| _version_ | 1828085287826227200 |
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| author | Sid E. O'Bryant Leigh A. Johnson Robert C. Barber Meredith N. Braskie Bradley Christian James R. Hall Nalini Hazra Kevin King Deydeep Kothapalli Stephanie Large David Mason Elizabeth Matsiyevskiy Roderick McColl Rajesh Nandy Raymond Palmer Melissa Petersen Nicole Philips Robert A. Rissman Yonggang Shi Arthur W. Toga Raul Vintimilla Rocky Vig Fan Zhang Kristine Yaffe for the HABLE Study Team |
| author_facet | Sid E. O'Bryant Leigh A. Johnson Robert C. Barber Meredith N. Braskie Bradley Christian James R. Hall Nalini Hazra Kevin King Deydeep Kothapalli Stephanie Large David Mason Elizabeth Matsiyevskiy Roderick McColl Rajesh Nandy Raymond Palmer Melissa Petersen Nicole Philips Robert A. Rissman Yonggang Shi Arthur W. Toga Raul Vintimilla Rocky Vig Fan Zhang Kristine Yaffe for the HABLE Study Team |
| author_sort | Sid E. O'Bryant |
| collection | DOAJ |
| description | Abstract Introduction Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. Methods Community‐dwelling Mexican Americans and non‐Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository. Results Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non‐Hispanic Whites. Discussion The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations. |
| first_indexed | 2024-04-11T04:36:38Z |
| format | Article |
| id | doaj.art-32c6a2cb86ac4675a0b0351004c82687 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-11T04:36:38Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-32c6a2cb86ac4675a0b0351004c826872022-12-28T09:12:13ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292021-01-01131n/an/a10.1002/dad2.12202The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristicsSid E. O'Bryant0Leigh A. Johnson1Robert C. Barber2Meredith N. Braskie3Bradley Christian4James R. Hall5Nalini Hazra6Kevin King7Deydeep Kothapalli8Stephanie Large9David Mason10Elizabeth Matsiyevskiy11Roderick McColl12Rajesh Nandy13Raymond Palmer14Melissa Petersen15Nicole Philips16Robert A. Rissman17Yonggang Shi18Arthur W. Toga19Raul Vintimilla20Rocky Vig21Fan Zhang22Kristine Yaffe23for the HABLE Study TeamInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USAImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USAWaisman Center, Departments of Physics and Psychiatry University of Wisconsin Madison Madison Wisconsin USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USAImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USADepartment of Neuroradiology Barrow Neurological Institute Phoenix Arizona USAImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USADepartment of Family Medicine University of North Texas Health Science Center Fort Worth Texas USAImaging Genetics Center, Stevens Neuroimaging and Informatics Institute Keck School of Medicine, USC Los Angeles California USADepartment of Radiology UT Southwestern Medical Center Dallas Texas USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USADepartment of Family Practice and Community Medicine, Joe R & Teresa Lozano Long School of Medicine The University of Texas Health Science Center at San Antonio San Antonio Texas USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USADepartment of Neurosciences University of California San Diego, La Jolla California USALaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC University of Southern California Los Angeles California USALaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC University of Southern California Los Angeles California USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USAImaging, Midtown Medical Imaging Fort Worth Texas USAInstitute for Translational Research University of North Texas Health Science Center Fort Worth Texas USADepartment of Psychiatry, Neurology, and Epidemiology and Biostatistics University of California San Francisco California USAAbstract Introduction Mexican Americans remain severely underrepresented in Alzheimer's disease (AD) research. The Health & Aging Brain among Latino Elders (HABLE) study was created to fill important gaps in the existing literature. Methods Community‐dwelling Mexican Americans and non‐Hispanic White adults and elders (age 50 and above) were recruited. All participants underwent comprehensive assessments including an interview, functional exam, clinical labs, informant interview, neuropsychological testing, and 3T magnetic resonance imaging (MRI) of the brain. Amyloid and tau positron emission tomography (PET) scans were added at visit 2. Blood samples were stored in the Biorepository. Results Data was examined from n = 1705 participants. Significant group differences were found in medical, demographic, and sociocultural factors. Cerebral amyloid and neurodegeneration imaging markers were significantly different between Mexican Americans and non‐Hispanic Whites. Discussion The current data provide strong support for continued investigations that examine the risk factors for and biomarkers of AD among diverse populations.https://doi.org/10.1002/dad2.12202Alzheimer's diseaseamyloidbiomarkersdiversityHispanicMexican American |
| spellingShingle | Sid E. O'Bryant Leigh A. Johnson Robert C. Barber Meredith N. Braskie Bradley Christian James R. Hall Nalini Hazra Kevin King Deydeep Kothapalli Stephanie Large David Mason Elizabeth Matsiyevskiy Roderick McColl Rajesh Nandy Raymond Palmer Melissa Petersen Nicole Philips Robert A. Rissman Yonggang Shi Arthur W. Toga Raul Vintimilla Rocky Vig Fan Zhang Kristine Yaffe for the HABLE Study Team The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Alzheimer's disease amyloid biomarkers diversity Hispanic Mexican American |
| title | The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics |
| title_full | The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics |
| title_fullStr | The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics |
| title_full_unstemmed | The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics |
| title_short | The Health & Aging Brain among Latino Elders (HABLE) study methods and participant characteristics |
| title_sort | health aging brain among latino elders hable study methods and participant characteristics |
| topic | Alzheimer's disease amyloid biomarkers diversity Hispanic Mexican American |
| url | https://doi.org/10.1002/dad2.12202 |
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