Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking
Objective: To investigate the mechanism of Renshen Guben oral liquid (RSGB) enhancing immune function. Materials and Methods: Network pharmacology and molecular docking were used to intuitively demonstrate the mechanism of immune regulation of RSGB. Results: A total of 112 active compounds of RSGB w...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | World Journal of Traditional Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.wjtcm.net/article.asp?issn=2311-8571;year=2023;volume=9;issue=4;spage=419;epage=429;aulast=Tan |
| _version_ | 1797221613147521024 |
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| author | Ying-Ying Tan Ying-Ying Liu Jing-Yuan Zhang Jia-Lin Li Pei-Zhi Ye Antony Stalin Xiao-Tian Fan Zhi-Hong Huang Bing Li Chao Wu Shan Lu Zhi-Shan Wu Xiao-Meng Zhang Guo-Liang Cheng Jia-Rui Wu Yan-Fang Mou |
| author_facet | Ying-Ying Tan Ying-Ying Liu Jing-Yuan Zhang Jia-Lin Li Pei-Zhi Ye Antony Stalin Xiao-Tian Fan Zhi-Hong Huang Bing Li Chao Wu Shan Lu Zhi-Shan Wu Xiao-Meng Zhang Guo-Liang Cheng Jia-Rui Wu Yan-Fang Mou |
| author_sort | Ying-Ying Tan |
| collection | DOAJ |
| description | Objective: To investigate the mechanism of Renshen Guben oral liquid (RSGB) enhancing immune function. Materials and Methods: Network pharmacology and molecular docking were used to intuitively demonstrate the mechanism of immune regulation of RSGB. Results: A total of 112 active compounds of RSGB were found, and 501 targets were predicted. Furthermore, 2974 immune targets were obtained from UniProt and NCBI Gene databases, and 111 common targets of RSGB and immunity were obtained. Among them, interleukin (IL) 6, tumor necrosis factor, AKT1, VEGFA, STAT3, MAPK1, SRC, EGFR, IL1B, and PTGS2 might be the key targets for RSGB to improve immunity. ClueGO and Kyoto Encyclopedia of Genes and Genomes analysis showed that the immunoregulatory mechanism of RSGB may find a relation with the B cell receptor signaling pathway and T cell receptor signaling pathway. Furthermore, this study preliminarily explored the mechanism of RSGB improving menopausal syndrome, polycystic ovary syndrome, and cancer-related fatigue by enhancing immunity. Conclusions: RSGB can improve the body's immunity through multicomponent, multitarget, and multipathway. In addition, RSGB can also improve the immune capacity of the body to assist in the treatment of diseases, which has great potential as an immunomodulator. |
| first_indexed | 2024-04-24T13:08:13Z |
| format | Article |
| id | doaj.art-32c71718f0a14fb685c698c286b86251 |
| institution | Directory Open Access Journal |
| issn | 2311-8571 |
| language | English |
| last_indexed | 2024-04-24T13:08:13Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Traditional Chinese Medicine |
| spelling | doaj.art-32c71718f0a14fb685c698c286b862512024-04-05T05:20:58ZengWolters Kluwer Medknow PublicationsWorld Journal of Traditional Chinese Medicine2311-85712023-01-019441942910.4103/2311-8571.391113Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular dockingYing-Ying TanYing-Ying LiuJing-Yuan ZhangJia-Lin LiPei-Zhi YeAntony StalinXiao-Tian FanZhi-Hong HuangBing LiChao WuShan LuZhi-Shan WuXiao-Meng ZhangGuo-Liang ChengJia-Rui WuYan-Fang MouObjective: To investigate the mechanism of Renshen Guben oral liquid (RSGB) enhancing immune function. Materials and Methods: Network pharmacology and molecular docking were used to intuitively demonstrate the mechanism of immune regulation of RSGB. Results: A total of 112 active compounds of RSGB were found, and 501 targets were predicted. Furthermore, 2974 immune targets were obtained from UniProt and NCBI Gene databases, and 111 common targets of RSGB and immunity were obtained. Among them, interleukin (IL) 6, tumor necrosis factor, AKT1, VEGFA, STAT3, MAPK1, SRC, EGFR, IL1B, and PTGS2 might be the key targets for RSGB to improve immunity. ClueGO and Kyoto Encyclopedia of Genes and Genomes analysis showed that the immunoregulatory mechanism of RSGB may find a relation with the B cell receptor signaling pathway and T cell receptor signaling pathway. Furthermore, this study preliminarily explored the mechanism of RSGB improving menopausal syndrome, polycystic ovary syndrome, and cancer-related fatigue by enhancing immunity. Conclusions: RSGB can improve the body's immunity through multicomponent, multitarget, and multipathway. In addition, RSGB can also improve the immune capacity of the body to assist in the treatment of diseases, which has great potential as an immunomodulator.http://www.wjtcm.net/article.asp?issn=2311-8571;year=2023;volume=9;issue=4;spage=419;epage=429;aulast=Tanimmunitymolecular dockingnetwork pharmacologyrenshen guben oral liquid |
| spellingShingle | Ying-Ying Tan Ying-Ying Liu Jing-Yuan Zhang Jia-Lin Li Pei-Zhi Ye Antony Stalin Xiao-Tian Fan Zhi-Hong Huang Bing Li Chao Wu Shan Lu Zhi-Shan Wu Xiao-Meng Zhang Guo-Liang Cheng Jia-Rui Wu Yan-Fang Mou Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking World Journal of Traditional Chinese Medicine immunity molecular docking network pharmacology renshen guben oral liquid |
| title | Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking |
| title_full | Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking |
| title_fullStr | Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking |
| title_full_unstemmed | Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking |
| title_short | Elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking |
| title_sort | elucidation of immune regulation mechanism of renshen guben oral liquid by network pharmacology and molecular docking |
| topic | immunity molecular docking network pharmacology renshen guben oral liquid |
| url | http://www.wjtcm.net/article.asp?issn=2311-8571;year=2023;volume=9;issue=4;spage=419;epage=429;aulast=Tan |
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