The immunoreactivity of GLI1 and VEGFA is a potential prognostic factor in kidney renal clear cell carcinoma

The immunoreactivity of GLI1 and VEGFA is a potential prognostic factor in kidney renal clear cell carcinoma

Abstract Kidney renal clear cell carcinoma (KIRC) is the most common type of kidney cancer and its pathogenesis is strongly associated with VHL–HIF–VEGF signaling. SHH ligand is the upstream SHH pathway regulator, while GLI1 is its major effector that stimulates as a transcription factor, i.a. expre...

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Main Authors: Anna Kotulak-Chrzaszcz, Jacek Kiezun, Mateusz Czajkowski, Marcin Matuszewski, Jakub Klacz, Bartlomiej E. Krazinski, Janusz Godlewski, Zbigniew Kmiec, Piotr M. Wierzbicki
Format: Article
Language:English
Published: BMC 2023-11-01
Series:BMC Cancer
Subjects:
KIRC
Sonic hedgehog pathway
SHH
GLI1
VEGFA
Prognostic factors
Online Access:https://doi.org/10.1186/s12885-023-11622-7

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