Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study
Abstract We analyzed database from the Taiwan National Health Insurance to investigate whether primary aldosteronism (PA) increases the risk of bladder stones. This retrospective nationwide population-based cohort study during the period of 1998–2011 compared patients with and without PA extracted b...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-86749-3 |
| _version_ | 1818978092398411776 |
|---|---|
| author | Mu-Chi Chung Cheng-Li Lin Ming-Ju Wu Cheng-Hsu Chen Jeng-Jer Shieh Chi-Jung Chung Chi-Yuan Li Tung-Min Yu |
| author_facet | Mu-Chi Chung Cheng-Li Lin Ming-Ju Wu Cheng-Hsu Chen Jeng-Jer Shieh Chi-Jung Chung Chi-Yuan Li Tung-Min Yu |
| author_sort | Mu-Chi Chung |
| collection | DOAJ |
| description | Abstract We analyzed database from the Taiwan National Health Insurance to investigate whether primary aldosteronism (PA) increases the risk of bladder stones. This retrospective nationwide population-based cohort study during the period of 1998–2011 compared patients with and without PA extracted by propensity score matching. Cox proportional hazard models and competing death risk model were used to estimate the hazard ratios (HRs), sub-hazard ratios (SHRs) and corresponding 95% confidence intervals (CIs). There were 3442 patients with PA and 3442 patients without PA. The incidence rate of bladder stones was 5.36 and 3.76 per 1000 person-years for both groups, respectively. In adjusted Cox hazard proportional regression models, the HR of bladder stones was 1.68 (95% CI 1.20–2.34) for patients with PA compared to individuals without PA. Considering the competing risk of death, the SHR of bladder stones still indicates a higher risk for PA than a comparison cohort (SHR, 1.79; 95% CI 1.30–2.44). PA, age, sex, and fracture number were the variables significantly contributing to the formation of bladder stones. In conclusion, PA is significantly associated with risk of bladder stones. |
| first_indexed | 2024-12-20T16:38:08Z |
| format | Article |
| id | doaj.art-32cc3d652c9d445ebb2867967ee30ffb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T16:38:08Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-32cc3d652c9d445ebb2867967ee30ffb2022-12-21T19:33:06ZengNature PortfolioScientific Reports2045-23222021-04-011111710.1038/s41598-021-86749-3Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort studyMu-Chi Chung0Cheng-Li Lin1Ming-Ju Wu2Cheng-Hsu Chen3Jeng-Jer Shieh4Chi-Jung Chung5Chi-Yuan Li6Tung-Min Yu7Division of Nephrology, Department of Medicine, Taichung Veterans General HospitalManagement Office for Health Data, China Medical University and HospitalDivision of Nephrology, Department of Medicine, Taichung Veterans General HospitalDivision of Nephrology, Department of Medicine, Taichung Veterans General HospitalRong Hsing Research Center for Translational Medicine, National Chung Hsing UniversityDepartment of Public Health, College of Public Health, China Medical UniversityGraduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical UniversityDivision of Nephrology, Department of Medicine, Taichung Veterans General HospitalAbstract We analyzed database from the Taiwan National Health Insurance to investigate whether primary aldosteronism (PA) increases the risk of bladder stones. This retrospective nationwide population-based cohort study during the period of 1998–2011 compared patients with and without PA extracted by propensity score matching. Cox proportional hazard models and competing death risk model were used to estimate the hazard ratios (HRs), sub-hazard ratios (SHRs) and corresponding 95% confidence intervals (CIs). There were 3442 patients with PA and 3442 patients without PA. The incidence rate of bladder stones was 5.36 and 3.76 per 1000 person-years for both groups, respectively. In adjusted Cox hazard proportional regression models, the HR of bladder stones was 1.68 (95% CI 1.20–2.34) for patients with PA compared to individuals without PA. Considering the competing risk of death, the SHR of bladder stones still indicates a higher risk for PA than a comparison cohort (SHR, 1.79; 95% CI 1.30–2.44). PA, age, sex, and fracture number were the variables significantly contributing to the formation of bladder stones. In conclusion, PA is significantly associated with risk of bladder stones.https://doi.org/10.1038/s41598-021-86749-3 |
| spellingShingle | Mu-Chi Chung Cheng-Li Lin Ming-Ju Wu Cheng-Hsu Chen Jeng-Jer Shieh Chi-Jung Chung Chi-Yuan Li Tung-Min Yu Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study Scientific Reports |
| title | Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study |
| title_full | Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study |
| title_fullStr | Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study |
| title_full_unstemmed | Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study |
| title_short | Primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study |
| title_sort | primary aldosteronism is associated with risk of urinary bladder stones in a nationwide cohort study |
| url | https://doi.org/10.1038/s41598-021-86749-3 |
| work_keys_str_mv | AT muchichung primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy AT chenglilin primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy AT mingjuwu primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy AT chenghsuchen primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy AT jengjershieh primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy AT chijungchung primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy AT chiyuanli primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy AT tungminyu primaryaldosteronismisassociatedwithriskofurinarybladderstonesinanationwidecohortstudy |