Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer
The intermediate states of the epithelial-to-mesenchymal transition (EMT) in cancer require further molecular characterisation. Here, the authors develop a method to evaluate EMT transformation and trajectories in cancer transcriptomics data, characterising EMT macro-states, including a hybrid state...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36439-7 |
| _version_ | 1811165827366387712 |
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| author | Guidantonio Malagoli Tagliazucchi Anna J. Wiecek Eloise Withnell Maria Secrier |
| author_facet | Guidantonio Malagoli Tagliazucchi Anna J. Wiecek Eloise Withnell Maria Secrier |
| author_sort | Guidantonio Malagoli Tagliazucchi |
| collection | DOAJ |
| description | The intermediate states of the epithelial-to-mesenchymal transition (EMT) in cancer require further molecular characterisation. Here, the authors develop a method to evaluate EMT transformation and trajectories in cancer transcriptomics data, characterising EMT macro-states, including a hybrid state, and EMT hallmarks. |
| first_indexed | 2024-04-10T15:43:04Z |
| format | Article |
| id | doaj.art-32cd2a1f15df4626bc98a6b500dd6014 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T15:43:04Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-32cd2a1f15df4626bc98a6b500dd60142023-02-12T12:16:48ZengNature PortfolioNature Communications2041-17232023-02-0114112010.1038/s41467-023-36439-7Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancerGuidantonio Malagoli Tagliazucchi0Anna J. Wiecek1Eloise Withnell2Maria Secrier3UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College LondonUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College LondonUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College LondonUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College LondonThe intermediate states of the epithelial-to-mesenchymal transition (EMT) in cancer require further molecular characterisation. Here, the authors develop a method to evaluate EMT transformation and trajectories in cancer transcriptomics data, characterising EMT macro-states, including a hybrid state, and EMT hallmarks.https://doi.org/10.1038/s41467-023-36439-7 |
| spellingShingle | Guidantonio Malagoli Tagliazucchi Anna J. Wiecek Eloise Withnell Maria Secrier Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer Nature Communications |
| title | Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer |
| title_full | Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer |
| title_fullStr | Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer |
| title_full_unstemmed | Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer |
| title_short | Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer |
| title_sort | genomic and microenvironmental heterogeneity shaping epithelial to mesenchymal trajectories in cancer |
| url | https://doi.org/10.1038/s41467-023-36439-7 |
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