The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC
Abstract Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different degrees of arterial stiffness is less understood. We th...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-12-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14593 |
| _version_ | 1827778868123009024 |
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| author | Babak Yazdani Graciela E. Delgado Marcus E. Kleber Gökhan Yücel Faeq Husain‐Syed Thomas D. Kraemer Jan Jochims Jan Leipe Winfried März Bernhard K. Krämer |
| author_facet | Babak Yazdani Graciela E. Delgado Marcus E. Kleber Gökhan Yücel Faeq Husain‐Syed Thomas D. Kraemer Jan Jochims Jan Leipe Winfried März Bernhard K. Krämer |
| author_sort | Babak Yazdani |
| collection | DOAJ |
| description | Abstract Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different degrees of arterial stiffness is less understood. We therefore analyzed long‐term data from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study in 3316 patients subdivided according to pulse pressure (PP) and RAAS‐blocker use. Patients on RAAS‐inhibition had higher renin and noradrenaline, lower aldosterone and aldosterone/renin quotient (ARQ). Renin and noradrenaline significantly predicted CVM in patients without RAAS‐blocker (HR = 1.17, 1.15) and in patients receiving angiotensin‐converting‐enzyme (ACE) inhibitors (HR = 1.17, 1.29), whereas aldosterone predicted CVM only in patients receiving ACE‐inhibitors (HR = 1.13). CVM was predicted independently from PP by renin, noradrenaline and angiotensin II. Independently from RAAS inhibition renin decreased and ARQs increased with rising PP. Furthermore, noradrenaline increased with PP, but only without ACE‐inhibition. The HR for CVM in the ACE‐inhibitor group were 1.29, 1.28, 1.29 for renin in the first, second and third PP quartiles and 1.22, and 1.19 for aldosterone in the second and fourth quartile. Furthermore, we showed that noradrenaline predicts CVM in all PP quartiles in patients with ACE‐inhibition. In the RAAS‐blocker‐free group, the HR for renin for CVM were 1.36 and 1.18 in the third and fourth PP quartiles, but neither aldosterone nor noradrenaline were predictive for CVM within the PP quartiles. Renin and noradrenaline are strong predictors of CVM regardless of RAAS blockade, whereas aldosterone is predictive only in the ACE‐inhibitor group. Catecholamines but not renin are associated with rising PP. |
| first_indexed | 2024-03-11T14:41:56Z |
| format | Article |
| id | doaj.art-32cda64685864d70ac3ba637e44514ac |
| institution | Directory Open Access Journal |
| issn | 1524-6175 1751-7176 |
| language | English |
| last_indexed | 2024-03-11T14:41:56Z |
| publishDate | 2022-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj.art-32cda64685864d70ac3ba637e44514ac2023-10-30T13:26:51ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762022-12-0124121587159710.1111/jch.14593The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURICBabak Yazdani0Graciela E. Delgado1Marcus E. Kleber2Gökhan Yücel3Faeq Husain‐Syed4Thomas D. Kraemer5Jan Jochims6Jan Leipe7Winfried März8Bernhard K. Krämer9Fifth Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanyFifth Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanyFifth Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanyFirst Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanySecond Department of Medicine University Medical Center Giessen UKGM Giessen GermanyDepartment of Nephrology and Hypertension Hannover Medical School Hanover GermanyFifth Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanyFifth Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanyFifth Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanyFifth Department of Medicine University Medical Center Mannheim UMM Faculty of Medicine of the University of Heidelberg Mannheim GermanyAbstract Although neurohormones and Renin‐Angiotensin‐Aldosterone‐System (RAAS) components are important predictors of cardiovascular mortality (CVM), their importance for predicting outcomes in patients with/without RAAS‐blockers and different degrees of arterial stiffness is less understood. We therefore analyzed long‐term data from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study in 3316 patients subdivided according to pulse pressure (PP) and RAAS‐blocker use. Patients on RAAS‐inhibition had higher renin and noradrenaline, lower aldosterone and aldosterone/renin quotient (ARQ). Renin and noradrenaline significantly predicted CVM in patients without RAAS‐blocker (HR = 1.17, 1.15) and in patients receiving angiotensin‐converting‐enzyme (ACE) inhibitors (HR = 1.17, 1.29), whereas aldosterone predicted CVM only in patients receiving ACE‐inhibitors (HR = 1.13). CVM was predicted independently from PP by renin, noradrenaline and angiotensin II. Independently from RAAS inhibition renin decreased and ARQs increased with rising PP. Furthermore, noradrenaline increased with PP, but only without ACE‐inhibition. The HR for CVM in the ACE‐inhibitor group were 1.29, 1.28, 1.29 for renin in the first, second and third PP quartiles and 1.22, and 1.19 for aldosterone in the second and fourth quartile. Furthermore, we showed that noradrenaline predicts CVM in all PP quartiles in patients with ACE‐inhibition. In the RAAS‐blocker‐free group, the HR for renin for CVM were 1.36 and 1.18 in the third and fourth PP quartiles, but neither aldosterone nor noradrenaline were predictive for CVM within the PP quartiles. Renin and noradrenaline are strong predictors of CVM regardless of RAAS blockade, whereas aldosterone is predictive only in the ACE‐inhibitor group. Catecholamines but not renin are associated with rising PP.https://doi.org/10.1111/jch.14593ACE‐inhibitorsarterial complianceatherosclerosiscardiovascular mortalitynoradrenalinepulse pressure |
| spellingShingle | Babak Yazdani Graciela E. Delgado Marcus E. Kleber Gökhan Yücel Faeq Husain‐Syed Thomas D. Kraemer Jan Jochims Jan Leipe Winfried März Bernhard K. Krämer The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC The Journal of Clinical Hypertension ACE‐inhibitors arterial compliance atherosclerosis cardiovascular mortality noradrenaline pulse pressure |
| title | The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC |
| title_full | The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC |
| title_fullStr | The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC |
| title_full_unstemmed | The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC |
| title_short | The renin‐angiotensin‐aldosterone system, neurohumoral axis and cardiovascular mortality in LURIC |
| title_sort | renin angiotensin aldosterone system neurohumoral axis and cardiovascular mortality in luric |
| topic | ACE‐inhibitors arterial compliance atherosclerosis cardiovascular mortality noradrenaline pulse pressure |
| url | https://doi.org/10.1111/jch.14593 |
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