Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma

Plectin plays a role in the migration and volume regulation of astrocytes: a potential biomarker of glioblastoma

Abstract Background The expression of aquaporin 4 (AQP4) and intermediate filament (IF) proteins is altered in malignant glioblastoma (GBM), yet the expression of the major IF-based cytolinker, plectin (PLEC), and its contribution to GBM migration and invasiveness, are unknown. Here, we assessed the...

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Main Authors: Maja Žugec, Borut Furlani, Maria J. Castañon, Boštjan Rituper, Irmgard Fischer, Giuseppe Broggi, Rosario Caltabiano, Giuseppe M. V. Barbagallo, Michelino Di Rosa, Daniele Tibullo, Rosalba Parenti, Nunzio Vicario, Saša Simčič, Victorio Martin Pozo Devoto, Gorazd B. Stokin, Gerhard Wiche, Jernej Jorgačevski, Robert Zorec, Maja Potokar
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Biomedical Science
Subjects:
Astrocyte
Glioblastoma
Plectin
Aquaporin 4
Intermediate filaments
Cytoskeleton
Online Access:https://doi.org/10.1186/s12929-024-01002-z

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