Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy
Booster vaccinations for pertussis are advised in many countries during childhood or adulthood. In a phase IV longitudinal interventional study, we assessed long-term immunity following an extra pertussis booster vaccination in children and adults. Children (9 years of age) were primed in infancy wi...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/5/693 |
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| author | Pauline Versteegen Axel A. Bonačić Marinović Pieter G. M. van Gageldonk Saskia van der Lee Lotte H. Hendrikx Elisabeth A. M. Sanders Guy A. M. Berbers Anne-Marie Buisman |
| author_facet | Pauline Versteegen Axel A. Bonačić Marinović Pieter G. M. van Gageldonk Saskia van der Lee Lotte H. Hendrikx Elisabeth A. M. Sanders Guy A. M. Berbers Anne-Marie Buisman |
| author_sort | Pauline Versteegen |
| collection | DOAJ |
| description | Booster vaccinations for pertussis are advised in many countries during childhood or adulthood. In a phase IV longitudinal interventional study, we assessed long-term immunity following an extra pertussis booster vaccination in children and adults. Children (9 years of age) were primed in infancy with either the Dutch whole cell pertussis (wP) vaccine (<i>n</i> = 49) or acellular pertussis (aP) vaccines (<i>n</i> = 59), and all children received a preschool aP booster. Adults (25–29 years, <i>n</i> = 86) were wP-primed in infancy and did not receive a preschool booster. All were followed-up for approximately 6 years. After the additional booster, antibody responses to pertussis were more heterogeneous but generally higher in adults compared with children, and additional modelling showed that antibody concentrations remained higher for at least a decade. Serologic parameters indicative of recent pertussis infection were more often found in aP-primed children (12%) compared with wP-primed individuals (2%) (<i>p</i> = 0.052). This suggests that the aP booster vaccination in aP-primed children offers less long-term protection against pertussis infection and consequently against transmission. Together, these data show that aP priming in combination with aP boosting may not be sufficient to prevent circulation and transmission, while wP-primed adults may benefit from enhanced long-lasting immunity. |
| first_indexed | 2024-03-10T01:40:10Z |
| format | Article |
| id | doaj.art-32ce92dc62c0403bbfc7ec9f0025313a |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T01:40:10Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-32ce92dc62c0403bbfc7ec9f0025313a2023-11-23T13:25:39ZengMDPI AGVaccines2076-393X2022-04-0110569310.3390/vaccines10050693Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in InfancyPauline Versteegen0Axel A. Bonačić Marinović1Pieter G. M. van Gageldonk2Saskia van der Lee3Lotte H. Hendrikx4Elisabeth A. M. Sanders5Guy A. M. Berbers6Anne-Marie Buisman7National Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The NetherlandsNational Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The NetherlandsNational Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The NetherlandsNational Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The NetherlandsDepartment of Paediatrics, Bovenij Hospital, P.O. Box 37610, 1030 BD Amsterdam, The NetherlandsNational Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The NetherlandsNational Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The NetherlandsNational Institute for Public Health and the Environment, Centre for Infectious Disease Control, P.O. Box 1, 3720 BA Bilthoven, The NetherlandsBooster vaccinations for pertussis are advised in many countries during childhood or adulthood. In a phase IV longitudinal interventional study, we assessed long-term immunity following an extra pertussis booster vaccination in children and adults. Children (9 years of age) were primed in infancy with either the Dutch whole cell pertussis (wP) vaccine (<i>n</i> = 49) or acellular pertussis (aP) vaccines (<i>n</i> = 59), and all children received a preschool aP booster. Adults (25–29 years, <i>n</i> = 86) were wP-primed in infancy and did not receive a preschool booster. All were followed-up for approximately 6 years. After the additional booster, antibody responses to pertussis were more heterogeneous but generally higher in adults compared with children, and additional modelling showed that antibody concentrations remained higher for at least a decade. Serologic parameters indicative of recent pertussis infection were more often found in aP-primed children (12%) compared with wP-primed individuals (2%) (<i>p</i> = 0.052). This suggests that the aP booster vaccination in aP-primed children offers less long-term protection against pertussis infection and consequently against transmission. Together, these data show that aP priming in combination with aP boosting may not be sufficient to prevent circulation and transmission, while wP-primed adults may benefit from enhanced long-lasting immunity.https://www.mdpi.com/2076-393X/10/5/693pertussisvaccinationserologyinfectionhuman studies |
| spellingShingle | Pauline Versteegen Axel A. Bonačić Marinović Pieter G. M. van Gageldonk Saskia van der Lee Lotte H. Hendrikx Elisabeth A. M. Sanders Guy A. M. Berbers Anne-Marie Buisman Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy Vaccines pertussis vaccination serology infection human studies |
| title | Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy |
| title_full | Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy |
| title_fullStr | Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy |
| title_full_unstemmed | Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy |
| title_short | Long-Term Immunogenicity upon Pertussis Booster Vaccination in Young Adults and Children in Relation to Priming Vaccinations in Infancy |
| title_sort | long term immunogenicity upon pertussis booster vaccination in young adults and children in relation to priming vaccinations in infancy |
| topic | pertussis vaccination serology infection human studies |
| url | https://www.mdpi.com/2076-393X/10/5/693 |
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