Proposal of an Appropriate Decalcification Method of Bone Marrow Biopsy Specimens in the Era of Expanding Genetic Molecular Study

Proposal of an Appropriate Decalcification Method of Bone Marrow Biopsy Specimens in the Era of Expanding Genetic Molecular Study

Background: The conventional method for decalcification of bone specimens uses hydrochloric acid (HCl) and is notorious for damaging cellular RNA, DNA, and proteins, thus complicating molecular and immunohistochemical analyses. A method that can effectively decalcify while preserving genetic materia...

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Bibliographic Details
Main Authors: Sung-Eun Choi, Soon Won Hong, Sun Och Yoon
Format: Article
Language:English
Published: Korean Society of Pathologists & the Korean Society for Cytopathology 2015-05-01
Series:Journal of Pathology and Translational Medicine
Subjects:
Decalcification technique
Ethylenediaminetetraacetic acid disodium salt dehydrate
Hydrochloric acid
RDO GOLD
Bone marrow
Online Access:http://www.jpatholtm.org/upload/pdf/jptm-49-3-236.pdf

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