Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line
Alzheimer's disease is associated with a loss of plasticity and cognitive functioning. Previous research has shown that repetitive transcranial magnetic stimulation (rTMS) boosts cortical neurotrophic factors, potentially addressing this loss. The current study aimed to expand these findings by...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Experimental Gerontology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0531556523002449 |
| _version_ | 1797615980686344192 |
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| author | M. Windy McNerney Eric P. Kraybill Sindhu Narayanan Fatemeh S. Mojabi Vaibhavi Venkataramanan Alesha Heath |
| author_facet | M. Windy McNerney Eric P. Kraybill Sindhu Narayanan Fatemeh S. Mojabi Vaibhavi Venkataramanan Alesha Heath |
| author_sort | M. Windy McNerney |
| collection | DOAJ |
| description | Alzheimer's disease is associated with a loss of plasticity and cognitive functioning. Previous research has shown that repetitive transcranial magnetic stimulation (rTMS) boosts cortical neurotrophic factors, potentially addressing this loss. The current study aimed to expand these findings by measuring brain-derived neurotrophic factor (BDNF), its downstream hippocampal signaling molecules, and behavioral effects of rTMS on the 3xTg-AD mouse line. 3xTg-AD (n = 24) and B6 wild-type controls (n = 26), aged 12 months, were given 14 days of consecutive rTMS at 10 Hz for 10 min. Following treatment, mice underwent a battery of behavioral tests and biochemical analysis of BDNF and its downstream cascades were evaluated via Western blot and ELISA. Results showed that brain stimulation did improve performance on the Object Place Task and increased hippocampal TrkB, ERK, and PLCγ in 3xTg-AD mice with minimal effects on wild-type mice. There was no significant difference in the levels of AKT and Truncated TrkB (TrkB.T1) between treatment and sham. Thus, rTMS has the potential to provide an efficacious non-invasive therapy for the treatment of Alzheimer's disease through activation of neurotrophic factor signaling. |
| first_indexed | 2024-03-11T07:34:44Z |
| format | Article |
| id | doaj.art-32d00846171b4d68941d2b9f3ab787d6 |
| institution | Directory Open Access Journal |
| issn | 1873-6815 |
| language | English |
| last_indexed | 2024-03-11T07:34:44Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Experimental Gerontology |
| spelling | doaj.art-32d00846171b4d68941d2b9f3ab787d62023-11-17T05:25:11ZengElsevierExperimental Gerontology1873-68152023-11-01183112323Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse lineM. Windy McNerney0Eric P. Kraybill1Sindhu Narayanan2Fatemeh S. Mojabi3Vaibhavi Venkataramanan4Alesha Heath5Mental Illness Research Education and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA; Corresponding author at: 3801 Miranda Ave., Mail Code 151Y, Palo Alto, CA 94304, USA.Mental Illness Research Education and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USAMedical Anthropology and Global Health, University of Washington, Seattle, WA, USAMental Illness Research Education and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USADepartment of Psychological and Brain Sciences, University of Louisville, Louisville, KY, USAMental Illness Research Education and Clinical Center (MIRECC), Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USAAlzheimer's disease is associated with a loss of plasticity and cognitive functioning. Previous research has shown that repetitive transcranial magnetic stimulation (rTMS) boosts cortical neurotrophic factors, potentially addressing this loss. The current study aimed to expand these findings by measuring brain-derived neurotrophic factor (BDNF), its downstream hippocampal signaling molecules, and behavioral effects of rTMS on the 3xTg-AD mouse line. 3xTg-AD (n = 24) and B6 wild-type controls (n = 26), aged 12 months, were given 14 days of consecutive rTMS at 10 Hz for 10 min. Following treatment, mice underwent a battery of behavioral tests and biochemical analysis of BDNF and its downstream cascades were evaluated via Western blot and ELISA. Results showed that brain stimulation did improve performance on the Object Place Task and increased hippocampal TrkB, ERK, and PLCγ in 3xTg-AD mice with minimal effects on wild-type mice. There was no significant difference in the levels of AKT and Truncated TrkB (TrkB.T1) between treatment and sham. Thus, rTMS has the potential to provide an efficacious non-invasive therapy for the treatment of Alzheimer's disease through activation of neurotrophic factor signaling.http://www.sciencedirect.com/science/article/pii/S0531556523002449Repetitive transcranial magnetic stimulationAlzheimer's diseaseBrain-derived neurotrophic factorObject place test3xTg-ADTrkB |
| spellingShingle | M. Windy McNerney Eric P. Kraybill Sindhu Narayanan Fatemeh S. Mojabi Vaibhavi Venkataramanan Alesha Heath Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line Experimental Gerontology Repetitive transcranial magnetic stimulation Alzheimer's disease Brain-derived neurotrophic factor Object place test 3xTg-AD TrkB |
| title | Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line |
| title_full | Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line |
| title_fullStr | Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line |
| title_full_unstemmed | Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line |
| title_short | Memory-related hippocampal brain-derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xTg-AD mouse line |
| title_sort | memory related hippocampal brain derived neurotrophic factor activation pathways from repetitive transcranial magnetic stimulation in the 3xtg ad mouse line |
| topic | Repetitive transcranial magnetic stimulation Alzheimer's disease Brain-derived neurotrophic factor Object place test 3xTg-AD TrkB |
| url | http://www.sciencedirect.com/science/article/pii/S0531556523002449 |
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