GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROME
Russian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological Agency; 16 Vtoraya Sovetskaya St., 191024 Saint Petersburg, RussiaPolymorphism of platelet glycoproteins GPIIIa (T1565C), GPIba (T434C), GPIIb (T2622G) and GPIa (A1648G) genes, responsible for...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2018-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/293 |
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| author | I. I. Zotova S. I. Kapustin S. V. Gritsaev N. V. Mineeva I. I. Krobinets Zh. Yu. Sidorova S. S. Bessmeltsev A. V. Chechetkin |
| author_facet | I. I. Zotova S. I. Kapustin S. V. Gritsaev N. V. Mineeva I. I. Krobinets Zh. Yu. Sidorova S. S. Bessmeltsev A. V. Chechetkin |
| author_sort | I. I. Zotova |
| collection | DOAJ |
| description | Russian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological Agency; 16 Vtoraya Sovetskaya St., 191024 Saint Petersburg, RussiaPolymorphism of platelet glycoproteins GPIIIa (T1565C), GPIba (T434C), GPIIb (T2622G) and GPIa (A1648G) genes, responsible for the formation of alloantigenic platelet systems HPA-1, -2, -3 and -5, in patients with chronic immune thrombocytopenia (ITP) and in control group (CG) was investigated. Among ITP patients, the proportion of homozygotes of the GPIIb 2622 GG (HPA-3b/3b) gene was more than 2 times higher than in CG: 23.9 % versus 11.4 % (odds ratio (OR) = 2.4, 95 % confidence interval (CI): 1.0–5.8, p = 0.05). The frequency of HPA-3a/3a (GPIIb 2622TT,843Ile/Ile) genotype was higher in ITP patients with 2–3rd degrees of hemorrhagic syndrome (HS): 55.6% versus 25.0% in the group with 0–1st degree of HS (OR = 3.8, 95 % CI: 1.3–10.7, p = 0.02). The obtained data suggest the effect of T2622G polymorphism GPIIb gene both on development of disease (2622 GG genotype), and on serious manifestations of HS (2622 TT genotype), which allows considering this polymorphism as unfavorable prognostic criterion in ITP patients. |
| first_indexed | 2024-04-09T20:25:07Z |
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| id | doaj.art-32d064fbc70744f6afc4adf6e5909f5d |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:25:07Z |
| publishDate | 2018-07-01 |
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| series | Онкогематология |
| spelling | doaj.art-32d064fbc70744f6afc4adf6e5909f5d2023-03-30T20:15:12ZrusABV-pressОнкогематология1818-83462413-40232018-07-01132939910.17650/1818-8346-2018-13-2-93-99273GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROMEI. I. Zotova0S. I. Kapustin1S. V. Gritsaev2N. V. Mineeva3I. I. Krobinets4Zh. Yu. Sidorova5S. S. Bessmeltsev6A. V. Chechetkin7Russian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological AgencyRussian Scientific Research Institute of Hematology and Transfusiology under the Federal Medico-Biological Agency; 16 Vtoraya Sovetskaya St., 191024 Saint Petersburg, RussiaPolymorphism of platelet glycoproteins GPIIIa (T1565C), GPIba (T434C), GPIIb (T2622G) and GPIa (A1648G) genes, responsible for the formation of alloantigenic platelet systems HPA-1, -2, -3 and -5, in patients with chronic immune thrombocytopenia (ITP) and in control group (CG) was investigated. Among ITP patients, the proportion of homozygotes of the GPIIb 2622 GG (HPA-3b/3b) gene was more than 2 times higher than in CG: 23.9 % versus 11.4 % (odds ratio (OR) = 2.4, 95 % confidence interval (CI): 1.0–5.8, p = 0.05). The frequency of HPA-3a/3a (GPIIb 2622TT,843Ile/Ile) genotype was higher in ITP patients with 2–3rd degrees of hemorrhagic syndrome (HS): 55.6% versus 25.0% in the group with 0–1st degree of HS (OR = 3.8, 95 % CI: 1.3–10.7, p = 0.02). The obtained data suggest the effect of T2622G polymorphism GPIIb gene both on development of disease (2622 GG genotype), and on serious manifestations of HS (2622 TT genotype), which allows considering this polymorphism as unfavorable prognostic criterion in ITP patients.https://oncohematology.abvpress.ru/ongm/article/view/293immune thrombocytopeniahemorrhagic syndromegene polymorphismgpiib genehpa-3b/3b (gpiib 2622 gg) genotypehpa-3a/3a (gpiib 2622tt) genotype |
| spellingShingle | I. I. Zotova S. I. Kapustin S. V. Gritsaev N. V. Mineeva I. I. Krobinets Zh. Yu. Sidorova S. S. Bessmeltsev A. V. Chechetkin GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROME Онкогематология immune thrombocytopenia hemorrhagic syndrome gene polymorphism gpiib gene hpa-3b/3b (gpiib 2622 gg) genotype hpa-3a/3a (gpiib 2622tt) genotype |
| title | GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROME |
| title_full | GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROME |
| title_fullStr | GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROME |
| title_full_unstemmed | GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROME |
| title_short | GPIIB ALLELIC POLYMORPHISM AS A FACTOR ASSOCIATED WITH THE PROBABILITY OF IMMUNE THROMBOCYTOPENIA AND THE SEVERITY OF HEMORRHAGIC SYNDROME |
| title_sort | gpiib allelic polymorphism as a factor associated with the probability of immune thrombocytopenia and the severity of hemorrhagic syndrome |
| topic | immune thrombocytopenia hemorrhagic syndrome gene polymorphism gpiib gene hpa-3b/3b (gpiib 2622 gg) genotype hpa-3a/3a (gpiib 2622tt) genotype |
| url | https://oncohematology.abvpress.ru/ongm/article/view/293 |
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