The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in India
Introduction: Robust data of C-reactive protein (CRP) are available in bacterial infection, and it can be utilized in this coronavirus disease 2019 (COVID-2019) pneumonia pandemic for initial assessment before planning of treatment in indoor setting compared to other inflammatory markers and compute...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Advanced Lung Health |
| Subjects: | |
| Online Access: | http://www.jalh.org/article.asp?issn=2772-7165;year=2023;volume=3;issue=1;spage=17;epage=24;aulast=Patil |
| _version_ | 1797866482211749888 |
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| author | Shital Patil Ganesh Narwade Uttareshvar Dhumal |
| author_facet | Shital Patil Ganesh Narwade Uttareshvar Dhumal |
| author_sort | Shital Patil |
| collection | DOAJ |
| description | Introduction: Robust data of C-reactive protein (CRP) are available in bacterial infection, and it can be utilized in this coronavirus disease 2019 (COVID-2019) pneumonia pandemic for initial assessment before planning of treatment in indoor setting compared to other inflammatory markers and computerized tomography (CT) severity. Methods: A prospective, observational, 12-week-follow-up study, included 1000 COVID-19 cases confirmed with real-time reverse transcription-polymerase chain reaction; all cases were assessed with lung involvement documented and categorized on high-resolution computerized tomography (HRCT) thorax, oxygen saturation, and inflammatory marker as CRP at entry point and follow-up. Age, gender, comorbidity, use of bilevel positive airway pressure/noninvasive ventilation (BiPAP/NIV), and outcome as with or without lung fibrosis as per CT severity were key observations. Statistical analysis is performed using Chi-square test. Results: The HRCT severity score at entry point has significant correlation with CRP titer [P < 0.00001]. CRP titer has significant association with duration of illness (P < 0.00001). Comorbidities has significant association with CRP titer (P < 0.00001). CRP titer has significant association with oxygen saturation at entry point (P < 0.00001). BiPAP/NIV requirement during hospitalization has significant association with CRP titer (P < 0.00001). Timing of BiPAP/NIV requirement has significant association with CRP titer (P < 0.00001). Follow-up CRP titer during hospitalization compared to entry point normal and abnormal CRP has significant association in post-COVID lung fibrosis (P < 0.00001). Conclusions: CRP has documented a very crucial role in COVID-19 pneumonia in predicting severity of illness, progression of illness, and sequential CRP titers that will help assessing response to treatment during hospitalization and analyzing post-COVID lung fibrosis. |
| first_indexed | 2024-04-09T23:24:54Z |
| format | Article |
| id | doaj.art-32d0e6a67c4e4441a3d9b75dea796d9b |
| institution | Directory Open Access Journal |
| issn | 2772-7165 2772-7173 |
| language | English |
| last_indexed | 2024-04-09T23:24:54Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Lung Health |
| spelling | doaj.art-32d0e6a67c4e4441a3d9b75dea796d9b2023-03-21T11:08:56ZengWolters Kluwer Medknow PublicationsJournal of Advanced Lung Health2772-71652772-71732023-01-0131172410.4103/jalh.jalh_20_22The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in IndiaShital PatilGanesh NarwadeUttareshvar DhumalIntroduction: Robust data of C-reactive protein (CRP) are available in bacterial infection, and it can be utilized in this coronavirus disease 2019 (COVID-2019) pneumonia pandemic for initial assessment before planning of treatment in indoor setting compared to other inflammatory markers and computerized tomography (CT) severity. Methods: A prospective, observational, 12-week-follow-up study, included 1000 COVID-19 cases confirmed with real-time reverse transcription-polymerase chain reaction; all cases were assessed with lung involvement documented and categorized on high-resolution computerized tomography (HRCT) thorax, oxygen saturation, and inflammatory marker as CRP at entry point and follow-up. Age, gender, comorbidity, use of bilevel positive airway pressure/noninvasive ventilation (BiPAP/NIV), and outcome as with or without lung fibrosis as per CT severity were key observations. Statistical analysis is performed using Chi-square test. Results: The HRCT severity score at entry point has significant correlation with CRP titer [P < 0.00001]. CRP titer has significant association with duration of illness (P < 0.00001). Comorbidities has significant association with CRP titer (P < 0.00001). CRP titer has significant association with oxygen saturation at entry point (P < 0.00001). BiPAP/NIV requirement during hospitalization has significant association with CRP titer (P < 0.00001). Timing of BiPAP/NIV requirement has significant association with CRP titer (P < 0.00001). Follow-up CRP titer during hospitalization compared to entry point normal and abnormal CRP has significant association in post-COVID lung fibrosis (P < 0.00001). Conclusions: CRP has documented a very crucial role in COVID-19 pneumonia in predicting severity of illness, progression of illness, and sequential CRP titers that will help assessing response to treatment during hospitalization and analyzing post-COVID lung fibrosis.http://www.jalh.org/article.asp?issn=2772-7165;year=2023;volume=3;issue=1;spage=17;epage=24;aulast=Patilcoronavirus disease 2019 pneumoniac-reactive proteininflammatory markeroxygen saturation |
| spellingShingle | Shital Patil Ganesh Narwade Uttareshvar Dhumal The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in India Journal of Advanced Lung Health coronavirus disease 2019 pneumonia c-reactive protein inflammatory marker oxygen saturation |
| title | The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in India |
| title_full | The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in India |
| title_fullStr | The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in India |
| title_full_unstemmed | The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in India |
| title_short | The Role of initial and follow-up C-reactive protein titer in COVID-19 pneumonia: A single-center study of 1000 cases in a tertiary care setting in India |
| title_sort | role of initial and follow up c reactive protein titer in covid 19 pneumonia a single center study of 1000 cases in a tertiary care setting in india |
| topic | coronavirus disease 2019 pneumonia c-reactive protein inflammatory marker oxygen saturation |
| url | http://www.jalh.org/article.asp?issn=2772-7165;year=2023;volume=3;issue=1;spage=17;epage=24;aulast=Patil |
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