The role of astrocytes in amyloid production and Alzheimer's disease
Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ) plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the brain. It is thought that Aβ plaques trigger NFT formation, neuronal cell death, neuroinflammation and gliosis a...
Main Authors: | Georgia R. Frost, Yue-Ming Li |
---|---|
Format: | Article |
Language: | English |
Published: |
The Royal Society
2017-01-01
|
Series: | Open Biology |
Subjects: | |
Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170228 |
Similar Items
-
Alternative Targets to Fight Alzheimer’s Disease: Focus on Astrocytes
by: Marta Valenza, et al.
Published: (2021-04-01) -
Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease
by: Deepali Singh
Published: (2022-08-01) -
A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APP<sup>Swe</sup>/PSEN1<sup>ΔE9</sup> Mice Model of Amyloid Pathology
by: Marie Tautou, et al.
Published: (2023-03-01) -
The Hidden Role of Non-Canonical Amyloid β Isoforms in Alzheimer’s Disease
by: Lukas Busch, et al.
Published: (2022-10-01) -
Sinomenine inhibits amyloid beta-induced astrocyte activation and protects neurons against indirect toxicity
by: Deepali Singh, et al.
Published: (2020-03-01)