Pathoadaptive mutations in Salmonella enterica isolated after serial passage in mice.

Pathoadaptive mutations in Salmonella enterica isolated after serial passage in mice.

How pathogenic bacteria adapt and evolve in the complex and variable environment of the host remains a largely unresolved question. Here we have used whole genome sequencing of Salmonella enterica serovar Typhimurium LT2 populations serially passaged in mice to identify mutations that adapt bacteria...

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Bibliographic Details
Main Authors: Sanna Koskiniemi, Henry S Gibbons, Linus Sandegren, Naeem Anwar, Gary Ouellette, Stacey Broomall, Mark Karavis, Paul McGregor, Alvin Liem, Ed Fochler, Lauren McNew, Carolyn Nicole Rosenzweig, Mikael Rhen, Evan W Skowronski, Dan I Andersson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3723669?pdf=render

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