TM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicine
Abstract Background As chromatographic techniques have advanced, many articles that analyze the constituting compounds of medicinal materials have been published in relation to Northeast Asian traditional medicine, including traditional Chinese medicine (TCM). TM-MC was launched in 2015, providing i...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | BMC Complementary Medicine and Therapies |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12906-023-04331-y |
| _version_ | 1797350116653268992 |
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| author | Sang-Kyun Kim Myung-Ku Lee Ho Jang Jeong-Ju Lee Sanghun Lee Yunji Jang Hyunchul Jang Anna Kim |
| author_facet | Sang-Kyun Kim Myung-Ku Lee Ho Jang Jeong-Ju Lee Sanghun Lee Yunji Jang Hyunchul Jang Anna Kim |
| author_sort | Sang-Kyun Kim |
| collection | DOAJ |
| description | Abstract Background As chromatographic techniques have advanced, many articles that analyze the constituting compounds of medicinal materials have been published in relation to Northeast Asian traditional medicine, including traditional Chinese medicine (TCM). TM-MC was launched in 2015, providing information about the chemical compounds in medicinal materials from chromatographic articles in PubMed. Since 2015, through continuous curation efforts, we have now released TM-MC 2.0 with significant improvements to the quantity and quality of the data ( https://tm-mc.kr ). Description TM-MC 2.0 contains 635 medicinal materials, 34,107 chemical compounds (21,306 identified and de-duplicated), 13,992 targets, 27,997 diseases, and 5,075 prescriptions (2,393 de-duplicated by name). The database provides the largest number of identified compounds for medicinal materials listed in the pharmacopoeia compared to all TCM databases. In particular, marker compounds of medicinal materials and many newly discovered compounds were added through the manual curation of recent chromatographic articles. Conclusion TM-MC 2.0 provides the largest collection of information about the chemical compounds of the medicinal materials listed in the Korean, Chinese, and Japanese pharmacopoeias. Our database can be utilized for network pharmacology in traditional medicine and for the compound screening of medicinal materials for modern drug discovery. |
| first_indexed | 2024-03-08T12:40:11Z |
| format | Article |
| id | doaj.art-32d293bba1694102b02859249fdf28de |
| institution | Directory Open Access Journal |
| issn | 2662-7671 |
| language | English |
| last_indexed | 2024-03-08T12:40:11Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary Medicine and Therapies |
| spelling | doaj.art-32d293bba1694102b02859249fdf28de2024-01-21T12:10:24ZengBMCBMC Complementary Medicine and Therapies2662-76712024-01-012411710.1186/s12906-023-04331-yTM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicineSang-Kyun Kim0Myung-Ku Lee1Ho Jang2Jeong-Ju Lee3Sanghun Lee4Yunji Jang5Hyunchul Jang6Anna Kim7KM Data Division, Korea Institute of Oriental MedicineKM Data Division, Korea Institute of Oriental MedicineKM Data Division, Korea Institute of Oriental MedicineDivision of Biomedical Research, Korea Research Institute of Bioscience & BiotechnologyKM Data Division, Korea Institute of Oriental MedicineKM Data Division, Korea Institute of Oriental MedicineKM Data Division, Korea Institute of Oriental MedicineKM Data Division, Korea Institute of Oriental MedicineAbstract Background As chromatographic techniques have advanced, many articles that analyze the constituting compounds of medicinal materials have been published in relation to Northeast Asian traditional medicine, including traditional Chinese medicine (TCM). TM-MC was launched in 2015, providing information about the chemical compounds in medicinal materials from chromatographic articles in PubMed. Since 2015, through continuous curation efforts, we have now released TM-MC 2.0 with significant improvements to the quantity and quality of the data ( https://tm-mc.kr ). Description TM-MC 2.0 contains 635 medicinal materials, 34,107 chemical compounds (21,306 identified and de-duplicated), 13,992 targets, 27,997 diseases, and 5,075 prescriptions (2,393 de-duplicated by name). The database provides the largest number of identified compounds for medicinal materials listed in the pharmacopoeia compared to all TCM databases. In particular, marker compounds of medicinal materials and many newly discovered compounds were added through the manual curation of recent chromatographic articles. Conclusion TM-MC 2.0 provides the largest collection of information about the chemical compounds of the medicinal materials listed in the Korean, Chinese, and Japanese pharmacopoeias. Our database can be utilized for network pharmacology in traditional medicine and for the compound screening of medicinal materials for modern drug discovery.https://doi.org/10.1186/s12906-023-04331-yMedicinal materialChemical compoundNortheast Asian traditional medicineChromatography article |
| spellingShingle | Sang-Kyun Kim Myung-Ku Lee Ho Jang Jeong-Ju Lee Sanghun Lee Yunji Jang Hyunchul Jang Anna Kim TM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicine BMC Complementary Medicine and Therapies Medicinal material Chemical compound Northeast Asian traditional medicine Chromatography article |
| title | TM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicine |
| title_full | TM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicine |
| title_fullStr | TM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicine |
| title_full_unstemmed | TM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicine |
| title_short | TM-MC 2.0: an enhanced chemical database of medicinal materials in Northeast Asian traditional medicine |
| title_sort | tm mc 2 0 an enhanced chemical database of medicinal materials in northeast asian traditional medicine |
| topic | Medicinal material Chemical compound Northeast Asian traditional medicine Chromatography article |
| url | https://doi.org/10.1186/s12906-023-04331-y |
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