The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats
Background/Aims The aim of this study is to investigate the effects of the Hericium erinaceum on an experimental colitis model. Methods Twenty-four Wistar albino were included in this study. Rats were divided into three groups. Group 1 (n = 8) was sham group. Group 2 is the group of chemically induc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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The Korean Association of Internal Medicine
2021-03-01
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| Series: | The Korean Journal of Internal Medicine |
| Subjects: | |
| Online Access: | http://www.kjim.org/upload/pdf/kjim-2019-050.pdf |
| _version_ | 1819112316240658432 |
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| author | Ali Durmus Ilgim Durmus Omer Bender Oguzhan Karatepe |
| author_facet | Ali Durmus Ilgim Durmus Omer Bender Oguzhan Karatepe |
| author_sort | Ali Durmus |
| collection | DOAJ |
| description | Background/Aims The aim of this study is to investigate the effects of the Hericium erinaceum on an experimental colitis model. Methods Twenty-four Wistar albino were included in this study. Rats were divided into three groups. Group 1 (n = 8) was sham group. Group 2 is the group of chemically induced by intrarectal administration of trinitrobenzene sulfonic acid (TNBS) resulting in colitis. Group 3 (n = 8) is the group that was treated 7 days before and 7 days after with H. erinaceum resulting in colitis. The activity of colitis was evaluated macroscopically and microscopically in rats. In other words, nitric oxide (NO) levels, malondialdehyde (MDA), interleukin 6 (IL-6), nuclear factor-kappa B (NF-κB) and, tumor necrosis factor-α (TNF-α) in addition to the myeloperoxidasem (MPO) activities was determined. Results The rate of TNBS-induced colitis caused to increase the level of MDA activities meaningfully in the colitis group than the control group. The results indicated that MDA (p = 0.001), NO (p = 0.001), IL-6 (p = 0.001), MPO (p = 0.878), TNF-α (p = 0.001), and NF-κB levels of treatment group decreased in the blood and colon tissues because of the H. erinaceum treatment when compared to the colitis group. H. erinaceum treatment was related to the declining of MDA, NF-κB, NO, IL-6, and TNF-α levels. Conclusions H. erinaceum had a positive effect on the colitis by reducing oxidative damage in blood and tissue. |
| first_indexed | 2024-12-22T04:11:34Z |
| format | Article |
| id | doaj.art-32d2d46e6d824f9387109bbb8a389fbc |
| institution | Directory Open Access Journal |
| issn | 1226-3303 2005-6648 |
| language | English |
| last_indexed | 2024-12-22T04:11:34Z |
| publishDate | 2021-03-01 |
| publisher | The Korean Association of Internal Medicine |
| record_format | Article |
| series | The Korean Journal of Internal Medicine |
| spelling | doaj.art-32d2d46e6d824f9387109bbb8a389fbc2022-12-21T18:39:30ZengThe Korean Association of Internal MedicineThe Korean Journal of Internal Medicine1226-33032005-66482021-03-0136Suppl 1S44S5210.3904/kjim.2019.050170397The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in ratsAli Durmus0Ilgim Durmus1Omer Bender2Oguzhan Karatepe3 Department of Surgery, Nisantasi University, Istanbul, Turkey Department of Medical Biotechnology, Acibadem University, Istanbul, Turkey Department of SHMYO (Health Occupation School), Yeni Yuzyil University, Istanbul, Turkey Department of SHMYO (Health Occupation School), Yeni Yuzyil University, Istanbul, TurkeyBackground/Aims The aim of this study is to investigate the effects of the Hericium erinaceum on an experimental colitis model. Methods Twenty-four Wistar albino were included in this study. Rats were divided into three groups. Group 1 (n = 8) was sham group. Group 2 is the group of chemically induced by intrarectal administration of trinitrobenzene sulfonic acid (TNBS) resulting in colitis. Group 3 (n = 8) is the group that was treated 7 days before and 7 days after with H. erinaceum resulting in colitis. The activity of colitis was evaluated macroscopically and microscopically in rats. In other words, nitric oxide (NO) levels, malondialdehyde (MDA), interleukin 6 (IL-6), nuclear factor-kappa B (NF-κB) and, tumor necrosis factor-α (TNF-α) in addition to the myeloperoxidasem (MPO) activities was determined. Results The rate of TNBS-induced colitis caused to increase the level of MDA activities meaningfully in the colitis group than the control group. The results indicated that MDA (p = 0.001), NO (p = 0.001), IL-6 (p = 0.001), MPO (p = 0.878), TNF-α (p = 0.001), and NF-κB levels of treatment group decreased in the blood and colon tissues because of the H. erinaceum treatment when compared to the colitis group. H. erinaceum treatment was related to the declining of MDA, NF-κB, NO, IL-6, and TNF-α levels. Conclusions H. erinaceum had a positive effect on the colitis by reducing oxidative damage in blood and tissue.http://www.kjim.org/upload/pdf/kjim-2019-050.pdffungal proteinscolitisratscolon |
| spellingShingle | Ali Durmus Ilgim Durmus Omer Bender Oguzhan Karatepe The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats The Korean Journal of Internal Medicine fungal proteins colitis rats colon |
| title | The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats |
| title_full | The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats |
| title_fullStr | The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats |
| title_full_unstemmed | The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats |
| title_short | The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats |
| title_sort | effect of hericium erinaceum on the prevention of chemically induced experimental colitis in rats |
| topic | fungal proteins colitis rats colon |
| url | http://www.kjim.org/upload/pdf/kjim-2019-050.pdf |
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