Synthesis and Antiproliferative Activity of Minor Hops Prenylflavonoids and New Insights on Prenyl Group Cyclization

Synthesis and Antiproliferative Activity of Minor Hops Prenylflavonoids and New Insights on Prenyl Group Cyclization

Synthesis of minor prenylflavonoids found in hops and their non-natural derivatives were performed. The antiproliferative activity of the obtained compounds against some human cancer cell lines was investigated. Using xanthohumol isolated from spent hops as a lead compound, a series of minor hop pre...

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Bibliographic Details
Main Authors: Jarosław Popłoński, Eliza Turlej, Sandra Sordon, Tomasz Tronina, Agnieszka Bartmańska, Joanna Wietrzyk, Ewa Huszcza
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
xanthohumol
isoxanthohumol
chalcone
cyclisation
antiproliferative activity
hops
spent hops
Online Access:http://www.mdpi.com/1420-3049/23/4/776

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