Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile
Background: The prevalence of obesity is increasing dramatically worldwide. Obesity injuries have been linked to the alteration of many health biomarkers in humans. Consuming a 2.5:1 ratio of omega-6 and omega-3 helps to restore standard health biomarkers. Hemp, the non-psychoactive variety of <i...
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| Format: | Article |
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MDPI AG
2023-02-01
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| Series: | Agriculture |
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| Online Access: | https://www.mdpi.com/2077-0472/13/2/449 |
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| author | Tasneem S. Abu Ghazal Hadil S. Subih Belal S. Obeidat Mofleh S. Awawdeh |
| author_facet | Tasneem S. Abu Ghazal Hadil S. Subih Belal S. Obeidat Mofleh S. Awawdeh |
| author_sort | Tasneem S. Abu Ghazal |
| collection | DOAJ |
| description | Background: The prevalence of obesity is increasing dramatically worldwide. Obesity injuries have been linked to the alteration of many health biomarkers in humans. Consuming a 2.5:1 ratio of omega-6 and omega-3 helps to restore standard health biomarkers. Hemp, the non-psychoactive variety of <i>Cannabis Sativa</i> L., has a long history of being used as a source of food, fiber, and medicine. One of its attractive features is the favorable omega-6:omega-3 ratio found in its seed oil (HSO), making it a promising functional food for mitigating obesity-related injuries. Methods: A total of 84 female Wistar rats were randomly allocated into four groups. Two control groups (<i>n</i> = 21 each) were fed with a standard diet supplemented with 10% HSO. Two other equivalent groups consumed a high-fat diet, and one was supplemented with 10% HSO. Rats were euthanized from each group at 5, 10, or 15 weeks to measure body weight change, food intake, and several health biomarkers. Results: The results demonstrated that body weight gain and triglycerides were lower (<i>p</i> ≤ 0.05) for the control group supplemented with HSO compared with the other groups. Adiponectin concentration was lower (<i>p</i> ≤ 0.05) in both the control and high-fat treated groups. Other biomarkers were comparable among treatment diets. Conclusion: Our results suggest the usefulness of HSO supplementation for the overall health status. |
| first_indexed | 2024-03-11T09:17:41Z |
| format | Article |
| id | doaj.art-32d4bf49508d486cb458bd3477b5679b |
| institution | Directory Open Access Journal |
| issn | 2077-0472 |
| language | English |
| last_indexed | 2024-03-11T09:17:41Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Agriculture |
| spelling | doaj.art-32d4bf49508d486cb458bd3477b5679b2023-11-16T18:31:20ZengMDPI AGAgriculture2077-04722023-02-0113244910.3390/agriculture13020449Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid ProfileTasneem S. Abu Ghazal0Hadil S. Subih1Belal S. Obeidat2Mofleh S. Awawdeh3Department of Nutrition, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Nutrition, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Animal Production, Faculty of Agriculture, Jordan University of Science and Technology, Irbid 22110, JordanDepartment of Pathology and Public Health, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, JordanBackground: The prevalence of obesity is increasing dramatically worldwide. Obesity injuries have been linked to the alteration of many health biomarkers in humans. Consuming a 2.5:1 ratio of omega-6 and omega-3 helps to restore standard health biomarkers. Hemp, the non-psychoactive variety of <i>Cannabis Sativa</i> L., has a long history of being used as a source of food, fiber, and medicine. One of its attractive features is the favorable omega-6:omega-3 ratio found in its seed oil (HSO), making it a promising functional food for mitigating obesity-related injuries. Methods: A total of 84 female Wistar rats were randomly allocated into four groups. Two control groups (<i>n</i> = 21 each) were fed with a standard diet supplemented with 10% HSO. Two other equivalent groups consumed a high-fat diet, and one was supplemented with 10% HSO. Rats were euthanized from each group at 5, 10, or 15 weeks to measure body weight change, food intake, and several health biomarkers. Results: The results demonstrated that body weight gain and triglycerides were lower (<i>p</i> ≤ 0.05) for the control group supplemented with HSO compared with the other groups. Adiponectin concentration was lower (<i>p</i> ≤ 0.05) in both the control and high-fat treated groups. Other biomarkers were comparable among treatment diets. Conclusion: Our results suggest the usefulness of HSO supplementation for the overall health status.https://www.mdpi.com/2077-0472/13/2/449hemp seed oil (HSO)obesitylipid profileomega-6:omega-3 ratioadiponectin |
| spellingShingle | Tasneem S. Abu Ghazal Hadil S. Subih Belal S. Obeidat Mofleh S. Awawdeh Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile Agriculture hemp seed oil (HSO) obesity lipid profile omega-6:omega-3 ratio adiponectin |
| title | Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile |
| title_full | Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile |
| title_fullStr | Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile |
| title_full_unstemmed | Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile |
| title_short | Hemp Seed Oil Effects on Female Rats Fed a High-Fat Diet and Modulating Adiponectin, Leptin, and Lipid Profile |
| title_sort | hemp seed oil effects on female rats fed a high fat diet and modulating adiponectin leptin and lipid profile |
| topic | hemp seed oil (HSO) obesity lipid profile omega-6:omega-3 ratio adiponectin |
| url | https://www.mdpi.com/2077-0472/13/2/449 |
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