Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer
Abstract Introduction Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC. The aim of this study is to explore the role and its underlying mechanism...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-023-01225-y |
| _version_ | 1797451743774113792 |
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| author | Wei Huang Yuliang Wu Ning Luo Xueqian Shuai Jing Guo Chunyan Wang Fanchun Yang Li Liu Shupeng Liu Zhongping Cheng |
| author_facet | Wei Huang Yuliang Wu Ning Luo Xueqian Shuai Jing Guo Chunyan Wang Fanchun Yang Li Liu Shupeng Liu Zhongping Cheng |
| author_sort | Wei Huang |
| collection | DOAJ |
| description | Abstract Introduction Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC. The aim of this study is to explore the role and its underlying mechanism of TRPM2 in OC. Methods The transcriptome data and clinical data were obtained from TCGA, GTEx, and GEO (GSE17260). DriverDBv3 and PrognoScan were used to analyze survival correlations. GSEA analysis was performed to uncover the underlying mechanism. The correlations between TRPM2 and immune score, immune cell infiltration were analyzed by TIMER2.0. Results TRPM2 was highly expressed in OC and high TRPM2 expression was related to the poor prognosis based on the Kaplan-Meier curves, univariate and multivariate analysis. The enrichment analysis suggested that TRPM2 was involved in immune-related pathways. Positive correlations were also observed between TRPM2 expression and immune score and immune cells covering B cells, T cells, macrophage, neutrophil, and myeloid dendritic cells. We also found that TRPM2 was positively related to immune checkpoints including ICOSLG, CD40, CD86, etc. TRPM2 expression had a positive correlation with M2 macrophage, but not with M1 macrophage. Besides, TRPM2 showed a strong positive correlation with pyroptosis-related genes including NLRP3, NLRC4, NOD2, NOD1, IL1B, GSDMD. Conclusion Our study demonstrated that TRPM2 is a poor prognostic prediction factor in ovarian cancer and is correlated to the immune microenvironment and pyroptosis. TRPM2 may act as a new immunotherapy target, which promoted the survival rate of OC patients. |
| first_indexed | 2024-03-09T14:58:52Z |
| format | Article |
| id | doaj.art-32d57b3fc4ac40beb60ad9587eed80f4 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-03-09T14:58:52Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-32d57b3fc4ac40beb60ad9587eed80f42023-11-26T13:59:35ZengBMCJournal of Ovarian Research1757-22152023-08-0116111410.1186/s13048-023-01225-yIdentification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancerWei Huang0Yuliang Wu1Ning Luo2Xueqian Shuai3Jing Guo4Chunyan Wang5Fanchun Yang6Li Liu7Shupeng Liu8Zhongping Cheng9Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineDepartment of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, Tongji University School of MedicineAbstract Introduction Ovarian cancer (OC) is one of the most common gynecologic malignant cancers with the current survival rate remaining low. TRPM2 has been reported as a survival predictor in various cancers but not in OC. The aim of this study is to explore the role and its underlying mechanism of TRPM2 in OC. Methods The transcriptome data and clinical data were obtained from TCGA, GTEx, and GEO (GSE17260). DriverDBv3 and PrognoScan were used to analyze survival correlations. GSEA analysis was performed to uncover the underlying mechanism. The correlations between TRPM2 and immune score, immune cell infiltration were analyzed by TIMER2.0. Results TRPM2 was highly expressed in OC and high TRPM2 expression was related to the poor prognosis based on the Kaplan-Meier curves, univariate and multivariate analysis. The enrichment analysis suggested that TRPM2 was involved in immune-related pathways. Positive correlations were also observed between TRPM2 expression and immune score and immune cells covering B cells, T cells, macrophage, neutrophil, and myeloid dendritic cells. We also found that TRPM2 was positively related to immune checkpoints including ICOSLG, CD40, CD86, etc. TRPM2 expression had a positive correlation with M2 macrophage, but not with M1 macrophage. Besides, TRPM2 showed a strong positive correlation with pyroptosis-related genes including NLRP3, NLRC4, NOD2, NOD1, IL1B, GSDMD. Conclusion Our study demonstrated that TRPM2 is a poor prognostic prediction factor in ovarian cancer and is correlated to the immune microenvironment and pyroptosis. TRPM2 may act as a new immunotherapy target, which promoted the survival rate of OC patients.https://doi.org/10.1186/s13048-023-01225-yPan-cancerTCGATRPM2PrognosisImmunologyPyroptosis |
| spellingShingle | Wei Huang Yuliang Wu Ning Luo Xueqian Shuai Jing Guo Chunyan Wang Fanchun Yang Li Liu Shupeng Liu Zhongping Cheng Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer Journal of Ovarian Research Pan-cancer TCGA TRPM2 Prognosis Immunology Pyroptosis |
| title | Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer |
| title_full | Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer |
| title_fullStr | Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer |
| title_full_unstemmed | Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer |
| title_short | Identification of TRPM2 as a prognostic factor correlated with immune infiltration in ovarian cancer |
| title_sort | identification of trpm2 as a prognostic factor correlated with immune infiltration in ovarian cancer |
| topic | Pan-cancer TCGA TRPM2 Prognosis Immunology Pyroptosis |
| url | https://doi.org/10.1186/s13048-023-01225-y |
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