Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report
Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In this report, we present a case of abrupt aggravation of proteinur...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society for Transplantation
2019-12-01
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| Series: | Korean Journal of Transplantation |
| Subjects: | |
| Online Access: | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/jkstn.2019.33.4.146 |
| _version_ | 1797329568785235968 |
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| author | Yoonhong Kim Dong Il Kim Jae Ryong Shim Tae Beom Lee Kwang Ho Yang Je Ho Ryu Hyun Jung Lee Byung Hyun Choi |
| author_facet | Yoonhong Kim Dong Il Kim Jae Ryong Shim Tae Beom Lee Kwang Ho Yang Je Ho Ryu Hyun Jung Lee Byung Hyun Choi |
| author_sort | Yoonhong Kim |
| collection | DOAJ |
| description | Pancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In this report, we present a case of abrupt aggravation of proteinuria after successful pancreas transplantation alone without evidence of calcineurin inhibitor (CNI) toxicity. A 22-year-old female patient with type I diabetes mellitus underwent pancreas transplantation alone. The patient already had retinopathy and mild proteinuria, which in this case, may mean diabetic nephropathy. Her glucose levels were managed within the normal range after successful pancreas transplantation. However, the amount of proteinuria fluctuated. Kidney needle biopsy was performed owing to severe elevation of proteinuria, 2 years after the transplantation. Electron microscopy revealed diabetic glomerulosclerosis without evidence of CNI toxicity. This case indicates that diabetic nephropathy can be aggravated after pancreas transplantation, despite well-managed glucose levels and absence of CNI toxicity. |
| first_indexed | 2024-03-08T07:07:30Z |
| format | Article |
| id | doaj.art-32d6a11071914963a5d3674d4bd463c8 |
| institution | Directory Open Access Journal |
| issn | 2671-8790 |
| language | English |
| last_indexed | 2024-03-08T07:07:30Z |
| publishDate | 2019-12-01 |
| publisher | Korean Society for Transplantation |
| record_format | Article |
| series | Korean Journal of Transplantation |
| spelling | doaj.art-32d6a11071914963a5d3674d4bd463c82024-02-03T04:17:11ZengKorean Society for TransplantationKorean Journal of Transplantation2671-87902019-12-0133414615210.4285/jkstn.2019.33.4.146jkstn.2019.33.4.146Progression of diabetic nephropathy after successful pancreas transplantation alone: a case reportYoonhong Kim0Dong Il Kim1Jae Ryong Shim2Tae Beom Lee3Kwang Ho Yang4Je Ho Ryu5Hyun Jung Lee6Byung Hyun Choi7Department of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaDepartment of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaDepartment of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaDepartment of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaDepartment of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaDepartment of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaDepartment of Pathology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaDepartment of Surgery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, KoreaPancreas transplantation is the only method that can nearly cure insulin-dependent diabetes mellitus. However, the effect of pancreas transplantation on patients with diabetic nephropathy has recently been considered controversial. In this report, we present a case of abrupt aggravation of proteinuria after successful pancreas transplantation alone without evidence of calcineurin inhibitor (CNI) toxicity. A 22-year-old female patient with type I diabetes mellitus underwent pancreas transplantation alone. The patient already had retinopathy and mild proteinuria, which in this case, may mean diabetic nephropathy. Her glucose levels were managed within the normal range after successful pancreas transplantation. However, the amount of proteinuria fluctuated. Kidney needle biopsy was performed owing to severe elevation of proteinuria, 2 years after the transplantation. Electron microscopy revealed diabetic glomerulosclerosis without evidence of CNI toxicity. This case indicates that diabetic nephropathy can be aggravated after pancreas transplantation, despite well-managed glucose levels and absence of CNI toxicity.http://journaleditor.inforang.com/journal/view.html?doi=10.4285/jkstn.2019.33.4.146pancreas transplantation; diabetic nephropathies; calcineurin inhibitors |
| spellingShingle | Yoonhong Kim Dong Il Kim Jae Ryong Shim Tae Beom Lee Kwang Ho Yang Je Ho Ryu Hyun Jung Lee Byung Hyun Choi Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report Korean Journal of Transplantation pancreas transplantation; diabetic nephropathies; calcineurin inhibitors |
| title | Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report |
| title_full | Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report |
| title_fullStr | Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report |
| title_full_unstemmed | Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report |
| title_short | Progression of diabetic nephropathy after successful pancreas transplantation alone: a case report |
| title_sort | progression of diabetic nephropathy after successful pancreas transplantation alone a case report |
| topic | pancreas transplantation; diabetic nephropathies; calcineurin inhibitors |
| url | http://journaleditor.inforang.com/journal/view.html?doi=10.4285/jkstn.2019.33.4.146 |
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