The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects
Stroke is a neurological disease responsible for significant morbidity and disability worldwide. However, there remains a dearth of effective therapies. The failure of many therapies for stroke in clinical trials has promoted the development of human cell-based models, such as brain organoids. Brain...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.646921/full |
| _version_ | 1818926340435345408 |
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| author | Guini Song Min Zhao Hanmin Chen Xiangyue Zhou Cameron Lenahan Yibo Ou Yue He |
| author_facet | Guini Song Min Zhao Hanmin Chen Xiangyue Zhou Cameron Lenahan Yibo Ou Yue He |
| author_sort | Guini Song |
| collection | DOAJ |
| description | Stroke is a neurological disease responsible for significant morbidity and disability worldwide. However, there remains a dearth of effective therapies. The failure of many therapies for stroke in clinical trials has promoted the development of human cell-based models, such as brain organoids. Brain organoids differ from pluripotent stem cells in that they recapitulate various key features of the human central nervous system (CNS) in three-dimensional (3D) space. Recent studies have demonstrated that brain organoids could serve as a new platform to study various neurological diseases. However, there are several limitations, such as the scarcity of glia and vasculature in organoids, which are important for studying stroke. Herein, we have summarized the application of brain organoid technology in stroke research, such as for modeling and transplantation purposes. We also discuss methods to overcome the limitations of brain organoid technology, as well as future prospects for its application in stroke research. Although there are many difficulties and challenges associated with brain organoid technology, it is clear that this approach will play a critical role in the future exploration of stroke treatment. |
| first_indexed | 2024-12-20T02:55:34Z |
| format | Article |
| id | doaj.art-32d7c1bdb35c4e218abce498f6847393 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-20T02:55:34Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-32d7c1bdb35c4e218abce498f68473932022-12-21T19:55:55ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022021-06-011510.3389/fncel.2021.646921646921The Application of Brain Organoid Technology in Stroke Research: Challenges and ProspectsGuini Song0Min Zhao1Hanmin Chen2Xiangyue Zhou3Cameron Lenahan4Yibo Ou5Yue He6Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Biomedical Sciences, Burrell College of Osteopathic Medicine, Las Cruces, NM, United StatesDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaStroke is a neurological disease responsible for significant morbidity and disability worldwide. However, there remains a dearth of effective therapies. The failure of many therapies for stroke in clinical trials has promoted the development of human cell-based models, such as brain organoids. Brain organoids differ from pluripotent stem cells in that they recapitulate various key features of the human central nervous system (CNS) in three-dimensional (3D) space. Recent studies have demonstrated that brain organoids could serve as a new platform to study various neurological diseases. However, there are several limitations, such as the scarcity of glia and vasculature in organoids, which are important for studying stroke. Herein, we have summarized the application of brain organoid technology in stroke research, such as for modeling and transplantation purposes. We also discuss methods to overcome the limitations of brain organoid technology, as well as future prospects for its application in stroke research. Although there are many difficulties and challenges associated with brain organoid technology, it is clear that this approach will play a critical role in the future exploration of stroke treatment.https://www.frontiersin.org/articles/10.3389/fncel.2021.646921/fullbrain organoidspluripotent stem cellstrokemodeltransplantation |
| spellingShingle | Guini Song Min Zhao Hanmin Chen Xiangyue Zhou Cameron Lenahan Yibo Ou Yue He The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects Frontiers in Cellular Neuroscience brain organoids pluripotent stem cell stroke model transplantation |
| title | The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects |
| title_full | The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects |
| title_fullStr | The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects |
| title_full_unstemmed | The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects |
| title_short | The Application of Brain Organoid Technology in Stroke Research: Challenges and Prospects |
| title_sort | application of brain organoid technology in stroke research challenges and prospects |
| topic | brain organoids pluripotent stem cell stroke model transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2021.646921/full |
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