DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen

DNAJA1- and conformational mutant p53-dependent inhibition of cancer cell migration by a novel compound identified through a virtual screen

Abstract Cancers are frequently addicted to oncogenic missense mutant p53 (mutp53). DNAJA1, a member of heat shock protein 40 (HSP40), also known as J-domain proteins (JDPs), plays a crucial role in the stabilization and oncogenic activity of misfolded or conformational mutp53 by binding to and prev...

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Bibliographic Details
Main Authors: Shigeto Nishikawa, Atsushi Kaida, Alejandro Parrales, Atul Ranjan, Mohamed Alalem, Hongyi Ren, Frank J. Schoenen, David K. Johnson, Tomoo Iwakuma
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-01229-5

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