Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma
Abstract Kidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration and prognosis in tumors. However, the role of Cuproptosis-related Ferroptosis genes (CRFGs) in KIRC has rarely been fully understood. Therefore,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01137-z |
| _version_ | 1797822933675016192 |
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| author | Gang Luo Lini Wang Ziyu Zheng Baobao Gao Chong Lei |
| author_facet | Gang Luo Lini Wang Ziyu Zheng Baobao Gao Chong Lei |
| author_sort | Gang Luo |
| collection | DOAJ |
| description | Abstract Kidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration and prognosis in tumors. However, the role of Cuproptosis-related Ferroptosis genes (CRFGs) in KIRC has rarely been fully understood. Therefore, we constructed a prognostic signature based on different expression of CRFGs in KIRC. All raw data of this study were extracted from public TCGA datasets. Cuproptosis and Ferroptosis genes were collected from the previous research. Finally, a total of 36 significantly different CRFGs were identified from TCGA–KIRC cohort. Six-gene signature (TRIB3, SLC2A3, PML, CD44, CDKN2A and MIOX) was identified by LASSO Cox regression based on the significantly different CRFGs. The CRFGs signature was correlated with worse overall survival and the AUC was 0.750. Functional enrichment indicated that CRFGs were mainly enriched in metabolism, drug resistance, tumor immunity pathways. Besides, the IC50 and immune checkpoint differentially expressed between different groups. The proposed 6-CRFGs signature is a promising biomarker to predict clinical outcomes and therapeutic responses for KIRC patient. |
| first_indexed | 2024-03-13T10:16:34Z |
| format | Article |
| id | doaj.art-32dda180a01245298f774a49dc324b11 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-13T10:16:34Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-32dda180a01245298f774a49dc324b112023-05-21T11:11:51ZengBMCEuropean Journal of Medical Research2047-783X2023-05-0128111110.1186/s40001-023-01137-zCuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinomaGang Luo0Lini Wang1Ziyu Zheng2Baobao Gao3Chong Lei4Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical UniversityDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical UniversityDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical UniversityDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical UniversityDepartment of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Fourth Military Medical UniversityAbstract Kidney renal clear cell carcinoma (KIRC) is a main subtype of kidney cancers. Cuproptosis and ferroptosis are correlated with immune infiltration and prognosis in tumors. However, the role of Cuproptosis-related Ferroptosis genes (CRFGs) in KIRC has rarely been fully understood. Therefore, we constructed a prognostic signature based on different expression of CRFGs in KIRC. All raw data of this study were extracted from public TCGA datasets. Cuproptosis and Ferroptosis genes were collected from the previous research. Finally, a total of 36 significantly different CRFGs were identified from TCGA–KIRC cohort. Six-gene signature (TRIB3, SLC2A3, PML, CD44, CDKN2A and MIOX) was identified by LASSO Cox regression based on the significantly different CRFGs. The CRFGs signature was correlated with worse overall survival and the AUC was 0.750. Functional enrichment indicated that CRFGs were mainly enriched in metabolism, drug resistance, tumor immunity pathways. Besides, the IC50 and immune checkpoint differentially expressed between different groups. The proposed 6-CRFGs signature is a promising biomarker to predict clinical outcomes and therapeutic responses for KIRC patient.https://doi.org/10.1186/s40001-023-01137-zSignatureClear Cell Renal Cell CarcinomaCuproptosisFerroptosis |
| spellingShingle | Gang Luo Lini Wang Ziyu Zheng Baobao Gao Chong Lei Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma European Journal of Medical Research Signature Clear Cell Renal Cell Carcinoma Cuproptosis Ferroptosis |
| title | Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma |
| title_full | Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma |
| title_fullStr | Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma |
| title_full_unstemmed | Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma |
| title_short | Cuproptosis-Related Ferroptosis genes for Predicting Prognosis in kidney renal clear cell carcinoma |
| title_sort | cuproptosis related ferroptosis genes for predicting prognosis in kidney renal clear cell carcinoma |
| topic | Signature Clear Cell Renal Cell Carcinoma Cuproptosis Ferroptosis |
| url | https://doi.org/10.1186/s40001-023-01137-z |
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