Separation of GVL from GVHD -location, location, location
Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for various hematologic malignancies. However, alloimmune response is a double-edged sword that mediates both beneficial graft-versus-leukemia (GVL) effects and harmful graft-versus-host disease (GVHD). Separation of GVL effec...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1296663/full |
| _version_ | 1797404498797264896 |
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| author | Takanori Teshima Daigo Hashimoto |
| author_facet | Takanori Teshima Daigo Hashimoto |
| author_sort | Takanori Teshima |
| collection | DOAJ |
| description | Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for various hematologic malignancies. However, alloimmune response is a double-edged sword that mediates both beneficial graft-versus-leukemia (GVL) effects and harmful graft-versus-host disease (GVHD). Separation of GVL effects from GVHD has been a topic of intense research to improve transplant outcomes, but reliable clinical strategies have not yet been established. Target tissues of acute GVHD are the skin, liver, and intestine, while leukemic stem cells reside in the bone marrow. Tissue specific effector T-cell migration is determined by a combination of inflammatory and chemotactic signals that interact with specific receptors on T cells. Specific inhibition of donor T cell migration to GVHD target tissues while preserving migration to the bone marrow may represent a novel strategy to separate GVL from GVHD. Furthermore, tissue specific GVHD therapy, promoting tissue tolerance, and targeting of the tumor immune microenvironment may also help to separate GVHD and GVL. |
| first_indexed | 2024-03-09T02:55:52Z |
| format | Article |
| id | doaj.art-32decd913a8c492d907164c187854ab4 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T02:55:52Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-32decd913a8c492d907164c187854ab42023-12-05T04:27:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.12966631296663Separation of GVL from GVHD -location, location, locationTakanori TeshimaDaigo HashimotoAllogeneic hematopoietic cell transplantation (HCT) is a curative therapy for various hematologic malignancies. However, alloimmune response is a double-edged sword that mediates both beneficial graft-versus-leukemia (GVL) effects and harmful graft-versus-host disease (GVHD). Separation of GVL effects from GVHD has been a topic of intense research to improve transplant outcomes, but reliable clinical strategies have not yet been established. Target tissues of acute GVHD are the skin, liver, and intestine, while leukemic stem cells reside in the bone marrow. Tissue specific effector T-cell migration is determined by a combination of inflammatory and chemotactic signals that interact with specific receptors on T cells. Specific inhibition of donor T cell migration to GVHD target tissues while preserving migration to the bone marrow may represent a novel strategy to separate GVL from GVHD. Furthermore, tissue specific GVHD therapy, promoting tissue tolerance, and targeting of the tumor immune microenvironment may also help to separate GVHD and GVL.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1296663/fullgraft-versus-leukemiagraft-versus-host diseaseintestinetumor immune environmenttissue tolerance |
| spellingShingle | Takanori Teshima Daigo Hashimoto Separation of GVL from GVHD -location, location, location Frontiers in Immunology graft-versus-leukemia graft-versus-host disease intestine tumor immune environment tissue tolerance |
| title | Separation of GVL from GVHD -location, location, location |
| title_full | Separation of GVL from GVHD -location, location, location |
| title_fullStr | Separation of GVL from GVHD -location, location, location |
| title_full_unstemmed | Separation of GVL from GVHD -location, location, location |
| title_short | Separation of GVL from GVHD -location, location, location |
| title_sort | separation of gvl from gvhd location location location |
| topic | graft-versus-leukemia graft-versus-host disease intestine tumor immune environment tissue tolerance |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1296663/full |
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